Effect of Fat Loading Test on Alteration of Plasma Lipids and Gastrointestinal Hormones in Dog with Ileo-jejunal Transposition

Experimental studies were carried out to investigate the effect of ileo-jejunal transposition (UT) upon the plasma lipids and gastrointestinal hormones after the oral administration of butter (2g/kg). Dogs undergoing either UT (n=6) or sham operation (n=5) were compared and the following results were obtained. 1) In both the UT and the sham groups the plasma triglyceride levels at 0 to 30 minutes after the ingestion of butter significantly increased after the operation. The plasma free fatty acid and cholesterol levels showed no differences afte surgery. 2) Five weeks after UT, a significant increase in the fasting plasma total glucagon-like immunoreactivity (total-GLI) level was observed, but the postprandial plasma total-GLI level showed no difference after IJT. 3) The plasma gastric inhibitory polypeptde response to butter ingestion was lower after IJT. The plasma gastrin and insulin levels showed no differences after IJT. The present studies suggest that the absorption of fat is not found to be affected by IJT. Digestion of intraluminal fats may play an important role in the release of enteroglucagon.