Effect of edaravone on the estimated glomerular filtration rate in patients with acute ischemic stroke and chronic kidney disease

Yuuko Tsukamoto, Shunya Takizawa, Wakoh Takahashi, Hiroyasu Mase, Hayato Miyachi, Toshio Miyata, Shigeharu Takagi

Research output: Contribution to journalArticlepeer-review

Abstract

The oxygen free radical scavenger edaravone is used in patients with acute ischemic stroke in Japan, but adverse reactions, especially decreased renal function, have raised concerns. To examine whether a patient's estimated glomerular filtration rate (eGFR) at admission can predict renal function deterioration after edaravone treatment, we retrospectively evaluated the effect of edaravone on eGFR in Japanese patients with acute ischemic stroke and chronic kidney disease (CKD). The baseline eGFR in the edaravone-treated group (73.5 ± 20.3 mL/min/1.73 m2; n = 408) at admission was significantly (P < .05) higher than that in the non-edaravone-treated group (51.9 ± 25.2 mL/min/1.73 m2; n = 41). The change in eGFR after treatment was categorized into 3 grades: nonexacerbation (≤10%), 10%-30% exacerbation, and >30% exacerbation. There was no significant difference in exacerbation grade between the edaravone-treated and non-edaravone-treated groups (χ2 = 3.134; P = .21). We next subdivided the edaravone-treated group according to eGFR at admission as either CKD (eGFR <60 mL/min/1.73 m2; n = 111) and non-CKD (n = 297). No significant decrease in eGFR was seen even in the edaravone-treated CKD group (most of whom were in stage 3 CKD). Decreased eGFR in stroke patients was found to be associated with stroke subtype (cardiogenic stroke), but not with infection. The present study demonstrates that eGFR at admission is not a good predictor of renal deterioration in edavarone-treated acute ischemic stroke patients, including those with stage 3 CKD.

Original languageEnglish
Pages (from-to)111-116
Number of pages6
JournalJournal of Stroke and Cerebrovascular Diseases
Volume20
Issue number2
DOIs
Publication statusPublished - 2011 Mar

Keywords

  • Chronic kidney disease
  • acute ischemic stroke
  • edaravone
  • estimated glomerular filtration rate
  • renal function

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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