Effect of donor type on volume of blood transfusions required after allogeneic hematopoietic cell transplantation

Saiko Kurosawa, Takuhiro Yamaguchi, Saori Nakabayashi, Moemi Kasane, Misato Tsubokura, Nao Iwashita, Yuki Minakawa, Ryuzaburo Ohtake, Kimihiko Kawamura, Yukiko Nishioka, Wataru Takeda, Tuneaki Hirakawa, Jun Aoki, Ayumu Ito, Takashi Tanaka, Yoshihiro Inamoto, Sung Won Kim, Minoru Kojima, Minoko Takanashi, Takahiro Fukuda

Research output: Contribution to journalArticlepeer-review

Abstract

We reviewed blood product use in 729 consecutive allogeneic hematopoietic cell transplantation (allo-HCT) recipients at our center to assess the volume of red blood cells (RBCs) and platelets required after allo-HCT. The median number of bags required by day 30 was 4 for RBCs (range 0–22) and 9.5 for platelets (0–53). Multivariate analysis showed that related peripheral blood stem cell transplantation (PBSCT) required a significantly lower RBC transfusion volume by day 30 compared to unrelated bone marrow transplantation (UBMT). PBSCT from haplo-identical related donors and cord blood transplantation (CBT) required a significantly greater RBC transfusion volume. For platelet transfusion, related and unrelated PBSCT required a significantly lower volume than UBMT, and CBT a greater volume. Other factors independently associated with greater RBC transfusion volume were male sex, disease status other than complete remission, and major ABO mismatch. For platelet transfusion, these were male sex, disease status, and HCT-specific comorbidity index of 1. Although the burden of blood transfusions may not be the most important factor when choosing a donor type, our findings may provide a foundation for nationwide strategies to prepare blood products and inform aspects of national healthcare expenditures.

Original languageEnglish
Pages (from-to)518-529
Number of pages12
JournalInternational journal of hematology
Volume113
Issue number4
DOIs
Publication statusPublished - 2021 Apr
Externally publishedYes

Keywords

  • Allogeneic hematopoietic cell transplantation
  • Blood transfusion
  • Donor
  • Platelet
  • Red blood cell
  • Transfusion independence

ASJC Scopus subject areas

  • Hematology

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