Effect of dietary seal and fish oils on triacylglycerol metabolism in rats

Hiroko Yoshida, Miwa Mawatari, Ikuo Ikeda, Katsumi Imaizumi, Akira Seto, Hiroaki Tsuji

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids were distributed mainly in the sn-1 and 3 positions of seal oil triacylglycerol and in the sn- 2 position of fish oil triacylglycerol. Seal oil or fish oil-rich fats having constant polyunsaturated/monounsaturated/saturated fatty acids and n-6/n-3 polyunsaturated fatty acid (PUFA) ratios were fed to rats for 3 wk. Control rats were fed on a fat containing linoleic acid as the sole PUFA. Seal oil more effectively lowered serum and liver triacylglycerol concentrations than fish oil. The activities of fatty acid synthase (FAS), glucose-6-phosphate dehydrogenase (G6PDH) and hepatic triacylglycerol lipase (HTGL) were significantly lower in the seal oil group than in the control group, whereas the activity of HTGL was significantly lower and the hepatic peroxisomal β- oxidation and activity of lipoprotein lipase (LPL) in adipose tissue were significantly higher in the fish oil group than in the control group. These observations suggest that the predominant hypotriacylglycerolemic effect of seal oil is caused by the suppression of fatty acid synthesis.

Original languageEnglish
Pages (from-to)411-421
Number of pages11
JournalJournal of nutritional science and vitaminology
Volume45
Issue number4
DOIs
Publication statusPublished - 1999 Jan 1
Externally publishedYes

Keywords

  • Docosahexaenoic acid
  • Eicosapentaenoic acid
  • Fatty acid synthesis
  • Positional fatty acid distribution
  • Seal oil

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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