Effect of dietary omega 3 phosphatidylcholine on obesity-related disorders in obese Otsuka Long-Evans Tokushima fatty rats

Bungo Shirouchi, Koji Nagao, Nao Inoue, Takeshi Ohkubo, Hidehiko Hibino, Teruyoshi Yanagita

Research output: Contribution to journalArticlepeer-review

92 Citations (Scopus)


Recent reports have shown that dietary phosphatidylcholine (PC) has various beneficial biological effects. Omega 3 polyunsaturated fatty acids (ω3 PUFAs) have also been reported to have lipid-lowering effects in animal models and human studies. In the present study, we investigated the effect of ω3 PUFAs containing PC (ω3-PC) on obesity-related disorders in Otsuka Long-Evans Tokushima fatty (OLETF) rats. Rats were fed semisynthetic diets that contained either 5% corn oil and 2% egg-PC or 5% corn oil and 2% ω3-PC for 4 weeks. During this 4 week feeding of the ω3-PC, the OLEFT rats showed a decrease of omental white adipose tissue weight. In addition, the ω3-PC diet significantly decreased liver weight and hepatic lipid levels in OLETF rats. These changes were attributable to the significant suppression of fatty acid synthase activity and significant enhancement in the activities of carnitine palmitoyltransferase and peroxisomal β-oxidation. Moreover, the ω3-PC diet reduced serum glucose levels concomitant with the increase of serum adiponectin levels. These results show that compared with egg-PC, ω3-PC can prevent or alleviate obesity-related disorders through the suppression of fatty acid synthesis, enhancement of fatty acid β-oxidation, and increase of the serum adiponectin level in OLETF rats.

Original languageEnglish
Pages (from-to)7170-7176
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Issue number17
Publication statusPublished - 2007 Aug 22
Externally publishedYes


  • Adiponectin
  • Docosahexaenoic acid
  • Eicosapentaenoic acid
  • Obesity-related disorders
  • Otsuka Long-Evans Tokushima fatty rats
  • Phosphatidylcholine
  • ω3 polyunsaturated fatty acids

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)


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