Effect of dietary oils on lymphocyte immunological activity in psychologically stressed mice

Motoko Oarada, Tohru Gonoi, Tsuyoshi Tsuzuki, Miki Igarashi, Katsuya Hirasaka, Takeshi Nikawa, Yuko Onishi, Takahito Toyotome, Katsuhiko Kamei, Teruo Miyazawa, Kiyotaka Nakagawa, Minoru Kashima, Nobuyuki Kurita

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Psychological stress has been shown to modulate immune functions. In this study, we investigated the effect of dietary oils (olive oil, soybean oil, and fish oil) on the social isolation stress-induced modulation of lymphocyte immunological activities in mice. In olive oil-fed, but not soybean oil- or fish oil-fed, mice, a 2-week isolation stress decreased the lymphocyte proliferative response, reduced the interferon-γ and interleukin (IL)-10 secretions and increased the IL-4 secretion by lymphocytes. The isolation stress reduced the arachidonic acid content of lymphocytes markedly, moderately, and not at all in the olive oil-, soybean oil-, and fish oil-fed mice, respectively. In the olive oil-fed, but not soybean oil- or fish oil-fed, mice, the isolation stress up-regulated the expression level of mRNA for splenic heat-shock protein 70 and increased lymphocyte sensitivity to the antiproliferative effect of corticosterone. This is the first demonstration that effect of psychological stress on lymphocyte immunological activities can vary depending upon the dietary fatty acid composition.

Original languageEnglish
Pages (from-to)174-182
Number of pages9
JournalBioscience, Biotechnology and Biochemistry
Volume71
Issue number1
DOIs
Publication statusPublished - 2007

Keywords

  • Arachidonic acid (AA) content
  • Dietary fish oil
  • Dietary olive oil
  • Lymphocyte immunological activity
  • Social isolation stress

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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