Effect of dietary oils on host resistance to fungal infection in psychologically stressed mice

Motoko Oarada, Miki Igarashi, Tsuyoshi Tsuzuki, Nobuyuki Kurita, Tohru Gonoi, Takeshi Nikawa, Katsuya Hirasaka, Teruo Miyazawa, Kiyotaka Nakagawa, Katsuhiko Kamei

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Psychological stress can modulate host defense against invading pathogens. In this study, we investigated the effect of dietary oils on social isolation stress- induced modulation of host resistance to Paracoccidioides brasiliensis. In olive oil-fed mice, 3 weeks of isolation stress resulted in temporarily delayed clearance of this fungus in the liver compared with group- housed mice. By contrast, in soybean oil-fed mice, isolation stress had no significant effect on antifungal activity. The olive oil-fed mice showed greater liver interferon (IFN)-γ and interleukin (IL)-6 production in response to infection as compared with the soybean oil-fed mice. In the olive oil-fed mice, isolation stress led to greater infection-induced IFN-y production in the liver compared with the group-housed animals. These results indicate that the modulatory effects of psychological stress on host resistance to P. brasiliensis can vary depending on dietary fatty acid composition.

Original languageEnglish
Pages (from-to)1994-1998
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Issue number9
Publication statusPublished - 2009


  • Antifungal activity
  • Dietary olive oil
  • Dietary soybean oil
  • Interferon (IFN)-γ
  • Social isolation stress

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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