Effect of dietary oils on host resistance to fungal infection in psychologically stressed mice

Motoko Oarada; Miki Igarashi; Tsuyoshi Tsuzuki; Nobuyuki Kurita; Tohru Gonoi; Takeshi Nikawa; Katsuya Hirasaka; Teruo Miyazawa; Kiyotaka Nakagawa; Katsuhiko Kamei

doi:10.1271/bbb.90184

Effect of dietary oils on host resistance to fungal infection in psychologically stressed mice

Motoko Oarada, Miki Igarashi, Tsuyoshi Tsuzuki, Nobuyuki Kurita, Tohru Gonoi, Takeshi Nikawa, Katsuya Hirasaka, Teruo Miyazawa, Kiyotaka Nakagawa, Katsuhiko Kamei

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Psychological stress can modulate host defense against invading pathogens. In this study, we investigated the effect of dietary oils on social isolation stress- induced modulation of host resistance to Paracoccidioides brasiliensis. In olive oil-fed mice, 3 weeks of isolation stress resulted in temporarily delayed clearance of this fungus in the liver compared with group- housed mice. By contrast, in soybean oil-fed mice, isolation stress had no significant effect on antifungal activity. The olive oil-fed mice showed greater liver interferon (IFN)-γ and interleukin (IL)-6 production in response to infection as compared with the soybean oil-fed mice. In the olive oil-fed mice, isolation stress led to greater infection-induced IFN-y production in the liver compared with the group-housed animals. These results indicate that the modulatory effects of psychological stress on host resistance to P. brasiliensis can vary depending on dietary fatty acid composition.

Original language	English
Pages (from-to)	1994-1998
Number of pages	5
Journal	Bioscience, Biotechnology and Biochemistry
Volume	73
Issue number	9
DOIs	https://doi.org/10.1271/bbb.90184
Publication status	Published - 2009

Keywords

Antifungal activity
Dietary olive oil
Dietary soybean oil
Interferon (IFN)-γ
Social isolation stress

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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Effect of dietary oils on host resistance to fungal infection in psychologically stressed mice. / Oarada, Motoko; Igarashi, Miki; Tsuzuki, Tsuyoshi; Kurita, Nobuyuki; Gonoi, Tohru; Nikawa, Takeshi; Hirasaka, Katsuya; Miyazawa, Teruo ; Nakagawa, Kiyotaka; Kamei, Katsuhiko.

In: Bioscience, Biotechnology and Biochemistry, Vol. 73, No. 9, 2009, p. 1994-1998.

Research output: Contribution to journal › Article › peer-review

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abstract = "Psychological stress can modulate host defense against invading pathogens. In this study, we investigated the effect of dietary oils on social isolation stress- induced modulation of host resistance to Paracoccidioides brasiliensis. In olive oil-fed mice, 3 weeks of isolation stress resulted in temporarily delayed clearance of this fungus in the liver compared with group- housed mice. By contrast, in soybean oil-fed mice, isolation stress had no significant effect on antifungal activity. The olive oil-fed mice showed greater liver interferon (IFN)-γ and interleukin (IL)-6 production in response to infection as compared with the soybean oil-fed mice. In the olive oil-fed mice, isolation stress led to greater infection-induced IFN-y production in the liver compared with the group-housed animals. These results indicate that the modulatory effects of psychological stress on host resistance to P. brasiliensis can vary depending on dietary fatty acid composition.",

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AU - Oarada, Motoko

AU - Igarashi, Miki

AU - Tsuzuki, Tsuyoshi

AU - Kurita, Nobuyuki

AU - Gonoi, Tohru

AU - Nikawa, Takeshi

AU - Hirasaka, Katsuya

AU - Miyazawa, Teruo

AU - Nakagawa, Kiyotaka

AU - Kamei, Katsuhiko

N1 - Funding Information: This study was supported in part by the Iijima Research Foundation.

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N2 - Psychological stress can modulate host defense against invading pathogens. In this study, we investigated the effect of dietary oils on social isolation stress- induced modulation of host resistance to Paracoccidioides brasiliensis. In olive oil-fed mice, 3 weeks of isolation stress resulted in temporarily delayed clearance of this fungus in the liver compared with group- housed mice. By contrast, in soybean oil-fed mice, isolation stress had no significant effect on antifungal activity. The olive oil-fed mice showed greater liver interferon (IFN)-γ and interleukin (IL)-6 production in response to infection as compared with the soybean oil-fed mice. In the olive oil-fed mice, isolation stress led to greater infection-induced IFN-y production in the liver compared with the group-housed animals. These results indicate that the modulatory effects of psychological stress on host resistance to P. brasiliensis can vary depending on dietary fatty acid composition.

AB - Psychological stress can modulate host defense against invading pathogens. In this study, we investigated the effect of dietary oils on social isolation stress- induced modulation of host resistance to Paracoccidioides brasiliensis. In olive oil-fed mice, 3 weeks of isolation stress resulted in temporarily delayed clearance of this fungus in the liver compared with group- housed mice. By contrast, in soybean oil-fed mice, isolation stress had no significant effect on antifungal activity. The olive oil-fed mice showed greater liver interferon (IFN)-γ and interleukin (IL)-6 production in response to infection as compared with the soybean oil-fed mice. In the olive oil-fed mice, isolation stress led to greater infection-induced IFN-y production in the liver compared with the group-housed animals. These results indicate that the modulatory effects of psychological stress on host resistance to P. brasiliensis can vary depending on dietary fatty acid composition.

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KW - Dietary olive oil

KW - Dietary soybean oil

KW - Interferon (IFN)-γ

KW - Social isolation stress

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SN - 0916-8451

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Effect of dietary oils on host resistance to fungal infection in psychologically stressed mice

Abstract

Keywords

ASJC Scopus subject areas

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