Effect of CpG ODN on monocytic myeloid derived suppressor cells

Hidekazu Shirota, Dennis M. Klinman

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

CpG oligonucleotides stimulate via TLR9 and enhance anti-tumor immunity, an effect attributed to the activation of NK and CD8+ T cells. Our recent work demonstrates that CpG ODN also induce monocytic myeloid-derived suppressor cells to mature into M1 macrophages, further aiding tumor elimination. This provides insight into the mechanism through which CpG promote tumor regression.

Original languageEnglish
Pages (from-to)780-782
Number of pages3
JournalOncoImmunology
Volume1
Issue number5
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • CpG ODN
  • CpG oligonucleotides
  • Immunotherapy
  • Myeloid derived suppressor cells
  • Myeloid-derived suppressor cells
  • TLR9
  • Toll like receptor
  • Tumor microenvironment
  • Tumor-associated macrophages

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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