Effect of copper pretreatment on toxicity and antitumor activity of cis-diamminedichloroplatinum in mice

Akira Naganuma, M. Satoh, N. Imura

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Effect of pretreatment with CuSO4 on toxicity and antitumor activity of cis-diamminedichloroplatinum (Cisplatin; CDDP) in mice were examined. Single subcutaneous administration of copper (CuSO4, 40 μmol/kg) 24 hr prior to injection of a lethal dose of CDDP (35 μmol/kg, sc) showed the most favorable effect among various administration conditions tested and completely prevented the manifestation of lethal toxicity of CDDP. In mice subcutaneously inoculated with Ehrlich tumor cells, the preadministration of copper also depressed the lethal and renal toxicity of CDDP without compromising its antitumor activity.

Original languageEnglish
Pages (from-to)265-274
Number of pages10
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume46
Issue number2
Publication statusPublished - 1984 Dec 1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Effect of copper pretreatment on toxicity and antitumor activity of cis-diamminedichloroplatinum in mice'. Together they form a unique fingerprint.

Cite this