Effect of controlled offset of focal position in cavitation-enhanced high-intensity focused ultrasound treatment

Kota Goto, Ryo Takagi, Takuya Miyashita, Hayato Jimbo, Shin Yoshizawa, Shin Ichiro Umemura

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

High-intensity focused ultrasound (HIFU) is a noninvasive treatment for tumors such as cancer. In this method, ultrasound is generated outside the body and focused to the target tissue. Therefore, physical and mental stresses on the patient are minimal. A drawback of the HIFU treatment is a long treatment time for a large tumor due to the small therapeutic volume by a single exposure. Enhancing the heating effect of ultrasound by cavitation bubbles may solve this problem. However, this is rather difficult because cavitation clouds tend to be formed backward from the focal point while ultrasonic intensity for heating is centered at the focal point. In this study, the focal points of the trigger pulses to generate cavitation were offset forward from those of the heating ultrasound to match the cavitation clouds with the heating patterns. Results suggest that the controlled offset of focal points makes the thermal coagulation more predictable.

Original languageEnglish
Article number07HF12
JournalJapanese journal of applied physics
Volume54
Issue number7
DOIs
Publication statusPublished - 2015 Jul 1

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

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