Effect of cocaine on the histaminergic neuron system in the rat brain

Chihiro Ito, K. Onodera, E. Sakurai, M. Sate, T. Watanabe

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

To examine the effect of cocaine on the brain histamine neuron system, histamine levels and histamine N-methyltransferase activity in the rat brain were measured after the administration of cocaine. Moreover, we examined the effect of L-histidine on cocaine-induced wheel-running behavior. The administration of cocaine (20 mg/kg) increased histamine revels and histamine N-methyltransferase activity in the striatum, nucleus accumbens, and amygdala 1 h later. The pretreatment with L-histidine (350 and 700 mg/kg) inhibited the cocaine (20 mg/kg)-induced increase of wheel-running activity in a dose- dependent manner. These findings suggest that cocaine activates the brain histamine neuron system, which may play the role of inhibiting the cocaine- induced wheel-running behavior.

Original languageEnglish
Pages (from-to)875-878
Number of pages4
JournalJournal of Neurochemistry
Volume69
Issue number2
Publication statusPublished - 1997 Aug 19

Keywords

  • Cocaine
  • Histamine N-methyltransferase
  • Histamine level
  • L- Histidine
  • Rat brain
  • Wheel-running behavior

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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  • Cite this

    Ito, C., Onodera, K., Sakurai, E., Sate, M., & Watanabe, T. (1997). Effect of cocaine on the histaminergic neuron system in the rat brain. Journal of Neurochemistry, 69(2), 875-878.