TY - JOUR
T1 - Effect of clenbuterol on peripheral airway obstruction in bronchial asthma
AU - Hida, W.
AU - Sakurai, M.
AU - Ichinose, M.
AU - Shindoh, C.
AU - Chonan, T.
AU - Kikuchi, Y.
AU - Inoue, H.
AU - Takishima, T.
PY - 1985
Y1 - 1985
N2 - A study was carried out in 6 patients with bronchial asthma to investigate the effects of clenbuterol, a β2-sympathomimetic bronchodilator, on peripheral airway obstruction. The basal lung functions of the patients were almost within normal range in both vital capacity (VC) and forced expiratory volume in 1 second (FEV1), but their maximal flow rates were lower in effort-independent phase of both maximal expiratory flow volume (MEFV) curve and partial expiratory flow volume (PEFV) curve. Furthermore, they demonstrated marked basal frequency dependence of dynamic compliance [CDdyn]. Oral administration of clenbuterol (40 μg) produced a significant increase in the maximal flow in effort-independent phase of both MEFV and PEFV curves, and markedly decreased frequency dependence of CDdyn in comparison with the baseline values, while it improved both VC and FEV1 to a lesser extent. These results suggest that clenbuterol preferentially reduced the peripheral airway obstruction in bronchial asthma.
AB - A study was carried out in 6 patients with bronchial asthma to investigate the effects of clenbuterol, a β2-sympathomimetic bronchodilator, on peripheral airway obstruction. The basal lung functions of the patients were almost within normal range in both vital capacity (VC) and forced expiratory volume in 1 second (FEV1), but their maximal flow rates were lower in effort-independent phase of both maximal expiratory flow volume (MEFV) curve and partial expiratory flow volume (PEFV) curve. Furthermore, they demonstrated marked basal frequency dependence of dynamic compliance [CDdyn]. Oral administration of clenbuterol (40 μg) produced a significant increase in the maximal flow in effort-independent phase of both MEFV and PEFV curves, and markedly decreased frequency dependence of CDdyn in comparison with the baseline values, while it improved both VC and FEV1 to a lesser extent. These results suggest that clenbuterol preferentially reduced the peripheral airway obstruction in bronchial asthma.
KW - Airway Obstruction
KW - Asthma
KW - Bronchodilator Agents
KW - Clenbuterol
KW - Lung Volume Measurements
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U2 - 10.1185/03007998509109643
DO - 10.1185/03007998509109643
M3 - Article
C2 - 3902376
AN - SCOPUS:0022373830
SN - 0300-7995
VL - 9
SP - 616
EP - 625
JO - Current Medical Research and Opinion
JF - Current Medical Research and Opinion
IS - 9
ER -