Effect of circadian rhythm on bronchomotor tone after deep inspiration in normal and in asthmatic subjects

Y. N. Liu; H. Sasaki; M. Ishii; K. Sekizawa; W. Hida; M. Ichinose; T. Takishima

Effect of circadian rhythm on bronchomotor tone after deep inspiration in normal and in asthmatic subjects

Y. N. Liu, H. Sasaki, M. Ishii, K. Sekizawa, W. Hida, M. Ichinose, T. Takishima

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Bronchomotor tone after deep inspiration and bronchial responsiveness to methacholine were studied at 4:00 A.M. and 4:00 P.M. in 14 normal and 13 asthmatic subjects. Bronchomotor tone was assessed with respiratory resistance (Rrs) measured by the forced oscillation method. Bronchial responsiveness to methacholine and baseline Rrs were higher at 4:00 A.M. than at 4:00 P.M. in both normal and asthmatic subjects (p < 0.01). The difference in methacholine threshold between 4:00 P.M. and 4:00 A.M. in asthmatics was similar to that in normal subjects. Immediately after deep inspiration, Rrs decreased more at 4:00 A.M. than at 4:00 P.M. in normal subjects. In contrast, asthmatic subjects showed a significantly greater immediate increase in Rrs after deep inspiration at 4:00 A.M. than at 4:00 P.M. It is suggested that the bronchoconstrictive effect after deep inspiration is a distinguishing characteristic of asthmatics.

Original language	English
Pages (from-to)	278-282
Number of pages	5
Journal	American Review of Respiratory Disease
Volume	132
Issue number	2
Publication status	Published - 1985

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Effect of circadian rhythm on bronchomotor tone after deep inspiration in normal and in asthmatic subjects'. Together they form a unique fingerprint.

Cite this

@article{0417c37b3fe648f1b6a66cc97f4ac073,

title = "Effect of circadian rhythm on bronchomotor tone after deep inspiration in normal and in asthmatic subjects",

abstract = "Bronchomotor tone after deep inspiration and bronchial responsiveness to methacholine were studied at 4:00 A.M. and 4:00 P.M. in 14 normal and 13 asthmatic subjects. Bronchomotor tone was assessed with respiratory resistance (Rrs) measured by the forced oscillation method. Bronchial responsiveness to methacholine and baseline Rrs were higher at 4:00 A.M. than at 4:00 P.M. in both normal and asthmatic subjects (p < 0.01). The difference in methacholine threshold between 4:00 P.M. and 4:00 A.M. in asthmatics was similar to that in normal subjects. Immediately after deep inspiration, Rrs decreased more at 4:00 A.M. than at 4:00 P.M. in normal subjects. In contrast, asthmatic subjects showed a significantly greater immediate increase in Rrs after deep inspiration at 4:00 A.M. than at 4:00 P.M. It is suggested that the bronchoconstrictive effect after deep inspiration is a distinguishing characteristic of asthmatics.",

author = "Liu, {Y. N.} and H. Sasaki and M. Ishii and K. Sekizawa and W. Hida and M. Ichinose and T. Takishima",

year = "1985",

language = "English",

volume = "132",

pages = "278--282",

journal = "American Journal of Respiratory and Critical Care Medicine",

issn = "1073-449X",

publisher = "American Thoracic Society",

number = "2",

}

TY - JOUR

T1 - Effect of circadian rhythm on bronchomotor tone after deep inspiration in normal and in asthmatic subjects

AU - Liu, Y. N.

AU - Sasaki, H.

AU - Ishii, M.

AU - Sekizawa, K.

AU - Hida, W.

AU - Ichinose, M.

AU - Takishima, T.

PY - 1985

Y1 - 1985

N2 - Bronchomotor tone after deep inspiration and bronchial responsiveness to methacholine were studied at 4:00 A.M. and 4:00 P.M. in 14 normal and 13 asthmatic subjects. Bronchomotor tone was assessed with respiratory resistance (Rrs) measured by the forced oscillation method. Bronchial responsiveness to methacholine and baseline Rrs were higher at 4:00 A.M. than at 4:00 P.M. in both normal and asthmatic subjects (p < 0.01). The difference in methacholine threshold between 4:00 P.M. and 4:00 A.M. in asthmatics was similar to that in normal subjects. Immediately after deep inspiration, Rrs decreased more at 4:00 A.M. than at 4:00 P.M. in normal subjects. In contrast, asthmatic subjects showed a significantly greater immediate increase in Rrs after deep inspiration at 4:00 A.M. than at 4:00 P.M. It is suggested that the bronchoconstrictive effect after deep inspiration is a distinguishing characteristic of asthmatics.

AB - Bronchomotor tone after deep inspiration and bronchial responsiveness to methacholine were studied at 4:00 A.M. and 4:00 P.M. in 14 normal and 13 asthmatic subjects. Bronchomotor tone was assessed with respiratory resistance (Rrs) measured by the forced oscillation method. Bronchial responsiveness to methacholine and baseline Rrs were higher at 4:00 A.M. than at 4:00 P.M. in both normal and asthmatic subjects (p < 0.01). The difference in methacholine threshold between 4:00 P.M. and 4:00 A.M. in asthmatics was similar to that in normal subjects. Immediately after deep inspiration, Rrs decreased more at 4:00 A.M. than at 4:00 P.M. in normal subjects. In contrast, asthmatic subjects showed a significantly greater immediate increase in Rrs after deep inspiration at 4:00 A.M. than at 4:00 P.M. It is suggested that the bronchoconstrictive effect after deep inspiration is a distinguishing characteristic of asthmatics.

UR - http://www.scopus.com/inward/record.url?scp=0021947099&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021947099&partnerID=8YFLogxK

M3 - Article

C2 - 3896077

AN - SCOPUS:0021947099

VL - 132

SP - 278

EP - 282

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 2

ER -

Effect of circadian rhythm on bronchomotor tone after deep inspiration in normal and in asthmatic subjects

Abstract

ASJC Scopus subject areas

Other files and links

Cite this