Effect of chlordimeform on nerve-muscle system of the larva of the waxmoth, Galleria mellonella

Daisuke Yamamoto, Jun ichi Fukami

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    The action of chlordimeform on the nerve-muscle preparation of the larvae of the waxmoth Galleria mellonella has been studied by means of microelectrodes. Exitatory junction potential evoked by nerve stimulation is reversibly suppressed by 2 × 10-3 M chlordimeform, and spike-like component is abolished. The resting membrane potential of the muscle fibre and the action potential from the nerve terminal are not affected at 5 × 10-3 M chlordimeform. The depolarizing membrane response caused by outward current and the effective membrane resistance are not appreciably affected. It appears that chlordimeform exerts its blocking action on the neuromuscular junction rather than the conductance mechanism of muscle fibre membrane.

    Original languageEnglish
    Pages (from-to)1511-1516
    Number of pages6
    JournalJournal of Insect Physiology
    Volume22
    Issue number11
    DOIs
    Publication statusPublished - 1976 Jan 1

    ASJC Scopus subject areas

    • Physiology
    • Insect Science

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