Effect of candidate gene polymorphisms on reproductive traits in a Large White pig population

Shuji Sato; Takashi Kikuchi; Yoshinobu Uemoto; Satoshi Mikawa; Keiichi Suzuki

doi:10.1111/asj.12580

Effect of candidate gene polymorphisms on reproductive traits in a Large White pig population

Shuji Sato, Takashi Kikuchi, Yoshinobu Uemoto, Satoshi Mikawa, Keiichi Suzuki

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The objective of this study was to test for association of candidate single nucleotide polymorphisms (SNPs) with sow prolificacy reproductive traits, such as litter size, ovulation rate and lifetime performance, in gilts of a Large White pig population. Preliminary research on 25 animals selected from the high- and low-performance groups of 347 animals with case-control studies indicated that seven genes were associated with total number of piglets born (TNB). Six of the seven genes were associated with reproductive traits, including TNB, number of piglets born alive (NBA) and average weight of piglet weaning (AWW). A MBL2 SNP was significantly associated with TNB and NBA in first parity. A CFB SNP was associated with TNB in first parity. An ACE SNP was associated with TNB in first and second parities. An EGF polymorphism was associated with TNB, NBA and AWW in second parity. A KCNC2 polymorphism was significantly associated with TNB and NBA in second parity. A SLC22A5 SNP was associated with TNB and NBA in second parity. Six candidate SNPs were associated with TNB; the only exception was a PRKAG3 polymorphism. A candidate gene approach enables some of these polymorphisms to be used in genetic improvement programs based on marker-assisted selection.

Original language	English
Pages (from-to)	1455-1463
Number of pages	9
Journal	Animal Science Journal
Volume	87
Issue number	12
DOIs	https://doi.org/10.1111/asj.12580
Publication status	Published - 2016 Dec 1

Keywords

pig
random residual effect
reproductive trait
single nucleotide polymorphism
total number of piglets born

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)

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10.1111/asj.12580

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title = "Effect of candidate gene polymorphisms on reproductive traits in a Large White pig population",

abstract = "The objective of this study was to test for association of candidate single nucleotide polymorphisms (SNPs) with sow prolificacy reproductive traits, such as litter size, ovulation rate and lifetime performance, in gilts of a Large White pig population. Preliminary research on 25 animals selected from the high- and low-performance groups of 347 animals with case-control studies indicated that seven genes were associated with total number of piglets born (TNB). Six of the seven genes were associated with reproductive traits, including TNB, number of piglets born alive (NBA) and average weight of piglet weaning (AWW). A MBL2 SNP was significantly associated with TNB and NBA in first parity. A CFB SNP was associated with TNB in first parity. An ACE SNP was associated with TNB in first and second parities. An EGF polymorphism was associated with TNB, NBA and AWW in second parity. A KCNC2 polymorphism was significantly associated with TNB and NBA in second parity. A SLC22A5 SNP was associated with TNB and NBA in second parity. Six candidate SNPs were associated with TNB; the only exception was a PRKAG3 polymorphism. A candidate gene approach enables some of these polymorphisms to be used in genetic improvement programs based on marker-assisted selection.",

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author = "Shuji Sato and Takashi Kikuchi and Yoshinobu Uemoto and Satoshi Mikawa and Keiichi Suzuki",

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AU - Kikuchi, Takashi

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AU - Suzuki, Keiichi

PY - 2016/12/1

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Effect of candidate gene polymorphisms on reproductive traits in a Large White pig population

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Keywords

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