Effect of CAMOSTAT in the treatment of reflux esophagitis after gastrectomy: An experimental study in rats and a pilot clinical study

Iwao Sasaki, Y. Suzuki, H. Naito, Y. Funayama, Y. Kamiyama, M. Takahashi, T. Matsuo, K. Fukushima, S. Matsuno, T. Sato

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Abstract

To determine the effect of oral administration of a protease inhibitor on the evolution of reflux esophagitis after gastric surgery studies were performed in both rats and clinical cases. 1) Experimental study: Four experimental operative procedures were performed in Sprague-Dawley rats to investigate effects on esophageal reflux content. Two weeks after surgery, the area of esophageal ulcer in TG (total gastrectomy with Billroth II reconstruction), TG+PBD (total gastrectomy and biliary and pancreatic juice diversion), TG+PR (total gastrectomy and biliary diversion) and TG+BR (total gastrectomy and pancreatic juice diversion) was 161.7 ± 25.5 mm2, 0 ± 0 mm2, 19.0 ± 7.1 mm2 and 0 ± 0 mm2, respectively. The area of esophageal ulcer one or two weeks after oral administration of CAMOSTAT was determined. There were significant differences between non-treated TG group and two week-treated group. 2) Clinical study: The subjective symptoms improved in 63% and 71.4% of patients at two and four weeks after administration of CAMOSTAT. Endoscopic findings also improved in 84% of cases four weeks after treatment. These results suggest that pancreatic juice is a major factor in the pathogenesis of reflux esophagitis after surgery, and oral administration of CAMOSTAT is an effective therapy.

Original languageEnglish
Pages (from-to)167-173
Number of pages7
JournalBiomedical Research
Volume10
Issue numberSUPPL. 1
Publication statusPublished - 1989 Dec 1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Sasaki, I., Suzuki, Y., Naito, H., Funayama, Y., Kamiyama, Y., Takahashi, M., Matsuo, T., Fukushima, K., Matsuno, S., & Sato, T. (1989). Effect of CAMOSTAT in the treatment of reflux esophagitis after gastrectomy: An experimental study in rats and a pilot clinical study. Biomedical Research, 10(SUPPL. 1), 167-173.