Effect of Brn-3a deficiency on parvalbumin-immunoreactive primary sensory neurons in the dorsal root ganglion

H. Ichikawa, Z. Mo, M. Xiang, T. Sugimoto

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Immunohistochemistry for parvalbumin, a marker for primary proprioceptors, was performed on the dorsal root ganglion (DRG) of wildtype and knockout mice for Brn-3a at postnatal day 0 and embryonic day 18.5. The DRG contained many parvalbumin-immunoreactive (ir) neurons in wildtype (5.4%) and knockout mice (5.6%). Cell size analysis demonstrated that such neurons were mostly medium-sized to large in these mice. Therefore, it is unlikely that the survival of proprioceptors is dependent upon Brn-3a in the DRG. In the dorsal column and gray matter of the spinal cord of knockout mice, however, parvalbumin-ir nerve fibers were sparse compared to wildtype mice. The number of parvalbumin-ir varicosities around motoneurons decreased in the mutant. Thus, our data suggest that Brn-3a may play an important role in the central projection and terminal formation of DRG proprioceptors in the spinal cord.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalDevelopmental Brain Research
Volume150
Issue number1
DOIs
Publication statusPublished - 2004 May 19
Externally publishedYes

Keywords

  • Development and regeneration
  • Immunohistochemistry
  • Knockout mouse
  • Parvalbumin
  • Proprioceptor
  • Sensory systems
  • Transcription factor

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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