Effect of angiotensin-converting enzyme inhibitor and exercise on hypertension and aortic wall stiffness in spontaneously hypertensive rats

Qi Guo, Naoyoshi Minami, Masahiro Kohzuki

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Endurance exercise training is known to increase aortic compliance in normotensive rats and subjects. Objective: We investigated the effect of perindopril, an angiotensin-converting enzyme inhibitor (ACEi) alone, exercise alone, and their combination on blood pressure, cardiac and aortic hypertrophy, and aortic wall stiffness in spontaneously hypertensive rats (SHR). Methods: Male SHR aged 7 weeks were assigned to 4 groups: sedentary control, exercise, perindopril, and combination with perindopril and exercise. Exercise was performed on a treadmill 5 days/week for 60 min at 20 m/min, and perindopril (1 mg/kg/day) was administered by gavage. Systolic blood pressure (SBP) and heart rate (HR) were measured every week with the tail-cuff method. At the age of 15 weeks aortic wall stiffness was estimated by pulse wave velocity in the aorta. Cardiac and aortic hypertrophy were evaluated by left ventricle/body weight (LV/BW) ratio and aorta/body weight (AO/BW) ratio, respectively. Results: Both exercise alone and perindopril alone significantly reduced SBP and HR, although antihypertensive effect of perindopril was greater than that of exercise. Perindopril, but not exercise, significantly reduced LV/BW, AO/BW, and aortic wall stiffness. Combination with perindopril and exercise had no additional effects to perindopril alone. Conclusions: We conclude that 1) aortic wall stiffness is closely related with aortic hypertrophy in growing SHR and 2) exercise training dose not modify aortic compliance of untreated- and ACEi-treated SHR.

Original languageEnglish
Pages (from-to)1605-1613
Number of pages9
JournalTherapeutic Research
Volume27
Issue number8
Publication statusPublished - 2006

Keywords

  • Angiotensin-converting enzyme inhibitor
  • Aortic compliance
  • Exercise
  • Spontaneously hypertensive rat

ASJC Scopus subject areas

  • Medicine(all)

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