Effect of anastrozole and tamoxifen on lipid metabolism in Japanese postmenopausal women with early breast cancer

Shojiro Sawada, Kazuhiko Sato, Masatoshi Kusuhara, Makoto Ayaori, Atsushi Yonemura, Kuniyoshi Tamaki, Hoshio Hiraide, Hidetaka Mochizuki, Fumitaka Ohsuzu

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19 Citations (Scopus)

Abstract

Endocrine therapies that profoundly decrease estrogen levels potentially have a detrimental effect on the cardiovascular system. This study evaluated the effect on lipid metabolism of one such agent, the new generation aromatase inhibitor anastrozole, compared with tamoxifen, when used as adjuvant treatment in postmenopausal Japanese women with early breast cancer. All patients had completed primary surgery and were randomized to anastrozole 1 mg once daily (n = 22) or tamoxifen 20 mg once daily (n = 22). Anastrozole significantly reduced levels of triglycerides and remnant-like particle cholesterol, whereas tamoxifen significantly increased these. Activity of lipoprotein lipase and levels of high-density lipoprotein cholesterol significantly increased after anastrozole treatment. In contrast, activity of hepatic triglyceride lipase, also a key enzyme of triglyceride metabolism, significantly decreased following treatment with tamoxifen. We thus conclude that in our study anastrozole had a beneficial effect on lipid profiles of postmenopausal women with early breast cancer after 12 weeks of treatment.

Original languageEnglish
Pages (from-to)134-141
Number of pages8
JournalActa Oncologica
Volume44
Issue number2
DOIs
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

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    Sawada, S., Sato, K., Kusuhara, M., Ayaori, M., Yonemura, A., Tamaki, K., Hiraide, H., Mochizuki, H., & Ohsuzu, F. (2005). Effect of anastrozole and tamoxifen on lipid metabolism in Japanese postmenopausal women with early breast cancer. Acta Oncologica, 44(2), 134-141. https://doi.org/10.1080/02841860510007585