Effect of ambrisentan on peripheral circulation in patients with systemic sclerosis

Hayakazu Sumida; Yoshihide Asano; Masaru Hatano; Naohiko Aozasa; Tetsuo Toyama; Kaname Akamata; Miki Miyazaki; Takashi Taniguchi; Takehiro Takahashi; Yohei Ichimura; Shinji Noda; Yoshihiro Kuwano; Koichi Yanaba; Shinichi Sato

doi:10.3109/14397595.2014.885377

Effect of ambrisentan on peripheral circulation in patients with systemic sclerosis

Hayakazu Sumida, Yoshihide Asano, Masaru Hatano, Naohiko Aozasa, Tetsuo Toyama, Kaname Akamata, Miki Miyazaki, Takashi Taniguchi, Takehiro Takahashi, Yohei Ichimura, Shinji Noda, Yoshihiro Kuwano, Koichi Yanaba, Shinichi Sato

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Systemic sclerosis (SSc) is characterized by disturbed blood circulation. The effect of ambrisentan, an endothelin-A receptor-selective antagonist, on impaired peripheral circulation in SSc remains largely elusive. Here we show SSc patients, whose clinical symptoms such as cyanosis and Raynaud's phenomenon, were ameliorated by the treatment with ambrisentan. Additionally, objective evaluations with thermography showed improvement of hand coldness in steady-state and cold challenge tests. Ambrisentan might have a potential to improve peripheral circulation in SSc.

Original language	English
Pages (from-to)	454-457
Number of pages	4
Journal	Modern Rheumatology
Volume	26
Issue number	3
DOIs	https://doi.org/10.3109/14397595.2014.885377
Publication status	Published - 2016 May 3
Externally published	Yes

Keywords

Ambrisentan
Cyanosis
Raynaud's phenomenon
Systemic sclerosis
Thermography

ASJC Scopus subject areas

Rheumatology

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10.3109/14397595.2014.885377

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title = "Effect of ambrisentan on peripheral circulation in patients with systemic sclerosis",

abstract = "Systemic sclerosis (SSc) is characterized by disturbed blood circulation. The effect of ambrisentan, an endothelin-A receptor-selective antagonist, on impaired peripheral circulation in SSc remains largely elusive. Here we show SSc patients, whose clinical symptoms such as cyanosis and Raynaud's phenomenon, were ameliorated by the treatment with ambrisentan. Additionally, objective evaluations with thermography showed improvement of hand coldness in steady-state and cold challenge tests. Ambrisentan might have a potential to improve peripheral circulation in SSc.",

keywords = "Ambrisentan, Cyanosis, Raynaud's phenomenon, Systemic sclerosis, Thermography",

author = "Hayakazu Sumida and Yoshihide Asano and Masaru Hatano and Naohiko Aozasa and Tetsuo Toyama and Kaname Akamata and Miki Miyazaki and Takashi Taniguchi and Takehiro Takahashi and Yohei Ichimura and Shinji Noda and Yoshihiro Kuwano and Koichi Yanaba and Shinichi Sato",

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doi = "10.3109/14397595.2014.885377",

language = "English",

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T1 - Effect of ambrisentan on peripheral circulation in patients with systemic sclerosis

AU - Sumida, Hayakazu

AU - Asano, Yoshihide

AU - Hatano, Masaru

AU - Aozasa, Naohiko

AU - Toyama, Tetsuo

AU - Akamata, Kaname

AU - Miyazaki, Miki

AU - Taniguchi, Takashi

AU - Takahashi, Takehiro

AU - Ichimura, Yohei

AU - Noda, Shinji

AU - Kuwano, Yoshihiro

AU - Yanaba, Koichi

AU - Sato, Shinichi

PY - 2016/5/3

Y1 - 2016/5/3

N2 - Systemic sclerosis (SSc) is characterized by disturbed blood circulation. The effect of ambrisentan, an endothelin-A receptor-selective antagonist, on impaired peripheral circulation in SSc remains largely elusive. Here we show SSc patients, whose clinical symptoms such as cyanosis and Raynaud's phenomenon, were ameliorated by the treatment with ambrisentan. Additionally, objective evaluations with thermography showed improvement of hand coldness in steady-state and cold challenge tests. Ambrisentan might have a potential to improve peripheral circulation in SSc.

AB - Systemic sclerosis (SSc) is characterized by disturbed blood circulation. The effect of ambrisentan, an endothelin-A receptor-selective antagonist, on impaired peripheral circulation in SSc remains largely elusive. Here we show SSc patients, whose clinical symptoms such as cyanosis and Raynaud's phenomenon, were ameliorated by the treatment with ambrisentan. Additionally, objective evaluations with thermography showed improvement of hand coldness in steady-state and cold challenge tests. Ambrisentan might have a potential to improve peripheral circulation in SSc.

KW - Ambrisentan

KW - Cyanosis

KW - Raynaud's phenomenon

KW - Systemic sclerosis

KW - Thermography

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Effect of ambrisentan on peripheral circulation in patients with systemic sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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