Effect of alahistidine on brain histamine content and seizure development

Wei wei Hu, Zhong Chen, Li sha Xu, Chun lei Jin, Eiko Sakurai, Kazuhiko Yanai

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To investigate the effect of alahistidine on brain histamine content and seizure development. METHODS: The kindling seizure was induced by ip injection with subconvulsant dose of pentylenetetrazole every 48 h. Monoamines and their metabolites were measured using a HPLC system and fluorometric assay. RESULT: Chronic low histamine feeding markedly decreased histamine content in cortex and hypothalamus, and promoted seizure development induced by pentylenetetrazole. However, alahistidine feed reversed the decreased histamine content and slowed seizure development caused by low histamine feed. Both low histamine and alahistidine feed had no effect on norepinephrine, dopamine and its metabolites. CONCLUSION: Alahistidine may affect histaminergic system and seizure development.

Original languageEnglish
Pages (from-to)197-200
Number of pages4
JournalZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
Volume33
Issue number3
Publication statusPublished - 2004 May
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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