Effect of acute water loading on urinary excretion of prostaglandin E in hypertensive patients

M. Sato, K. Abe, T. Haruyama, M. Yasujima, Y. Imai, M. Hiwatari, Y. Kasai, J. Tajima, S. Itoh, M. Seino, S. Chiba, T. Goto, K. Yoshinaga

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Abstract

To assess the relationship of urine flow to the urinary excretion of prostaglandin E (PGE), urinary excretion of PGE was measured before and after acute water loading (20 ml/kg orally) in patients with hypertension. Water loading promptly increased urinary excretion of PGE as well as urine flow rate and decreased urine osmolality (all p<0.001), but did not affect urinary excretions of sodium, potassium and creatinine, plasma renin activity and plasma aldosterone concentration. There was a significant positive correlation between urine flow rates and urinary PGE excretion rate (p<0.01). Urinary PGE concentration correlated negatively with urine flow rate when the flow was lower than 5 ml/min (p<0.01), whereas it did not change when the urine flow rate was larger than 5 ml/min. These results may support the hypothesis that urinary excretion of PGE is determined mainly by urine flow rate in the situation of water diuresis.

Original languageEnglish
Pages (from-to)517-524
Number of pages8
JournalProstaglandins Leukotrienes and Medicine
Volume8
Issue number5
Publication statusPublished - 1982 Aug 23

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology

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    Sato, M., Abe, K., Haruyama, T., Yasujima, M., Imai, Y., Hiwatari, M., Kasai, Y., Tajima, J., Itoh, S., Seino, M., Chiba, S., Goto, T., & Yoshinaga, K. (1982). Effect of acute water loading on urinary excretion of prostaglandin E in hypertensive patients. Prostaglandins Leukotrienes and Medicine, 8(5), 517-524.