Effect of a magnetic field on the orientation of hen egg-white lysozyme crystals

Shin Ichiro Yanagiya, Gen Sazaki, Stephen D. Durbin, Satoru Miyashita, Toshitaka Nakada, Hiroshi Komatsu, Kazuo Watanabe, Mitsuhiro Motokawa

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

Recent experiments have shown that lysozyme crystallization in a magnetic field of the order of 1 T can result in a significant degree of orientation of the crystals. We present more extensive experimental results and propose a model to account for this phenomenon. Because of the small susceptibility anisotropy of most protein molecules, the orienting effect is unimportant for smaller aggregates, even those much larger than a critical nucleus. However, during sedimentation crystals grow larger and are more likely to become aligned. The degree of orientation thus depends on crystal growth rate and container geometry, in addition to magnetic field strength, as we have confirmed experimentally.

Original languageEnglish
Pages (from-to)319-324
Number of pages6
JournalJournal of Crystal Growth
Volume196
Issue number2-4
DOIs
Publication statusPublished - 1999 Jan 15

Keywords

  • Lysozyme
  • Magnetic field
  • Magnetic orientation
  • Protein crystallization

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Inorganic Chemistry
  • Materials Chemistry

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