Abstract
Edaravone has been reported to have a radioprotective effect at high concentrations. We now report that a lower dose of edaravone enhanced X-ray-induced apoptosis of some cell lines harboring p53 wild-type status, such as MOLT-4, Nalm-6, and HepG2. The knock-down of p53 using siRNA in MOLT-4 cells abolished the radiosensitizing effect of edaravone. Enhanced phosphorylations of p53 at Ser 15 and Ser 20 and up-regulation of PUMA, a p53 target protein, were observed after X-irradiation in the presence of edaravone. We conclude that the low dose of edaravone sensitized cells to X-irradiation by promoting the p53-dependent apoptotic signaling pathway.
| Original language | English |
|---|---|
| Pages (from-to) | 52-57 |
| Number of pages | 6 |
| Journal | Cancer Letters |
| Volume | 293 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2010 Jul |
Keywords
- Apoptosis
- Edaravone
- P53
- Radiosensitizer
ASJC Scopus subject areas
- Oncology
- Cancer Research
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Sasano, N., Enomoto, A., Hosoi, Y., Katsumura, Y., Matsumoto, Y., Morita, A., Shiraishi, K., Miyagawa, K., Igaki, H., & Nakagawa, K. (2010). Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations. Cancer Letters, 293(1), 52-57. https://doi.org/10.1016/j.canlet.2009.12.020