Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations

N. Sasano, A. Enomoto, Y. Hosoi, Y. Katsumura, Y. Matsumoto, A. Morita, K. Shiraishi, K. Miyagawa, H. Igaki, K. Nakagawa

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Edaravone has been reported to have a radioprotective effect at high concentrations. We now report that a lower dose of edaravone enhanced X-ray-induced apoptosis of some cell lines harboring p53 wild-type status, such as MOLT-4, Nalm-6, and HepG2. The knock-down of p53 using siRNA in MOLT-4 cells abolished the radiosensitizing effect of edaravone. Enhanced phosphorylations of p53 at Ser 15 and Ser 20 and up-regulation of PUMA, a p53 target protein, were observed after X-irradiation in the presence of edaravone. We conclude that the low dose of edaravone sensitized cells to X-irradiation by promoting the p53-dependent apoptotic signaling pathway.

Original languageEnglish
Pages (from-to)52-57
Number of pages6
JournalCancer Letters
Volume293
Issue number1
DOIs
Publication statusPublished - 2010 Jul

Keywords

  • Apoptosis
  • Edaravone
  • P53
  • Radiosensitizer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations'. Together they form a unique fingerprint.

  • Cite this

    Sasano, N., Enomoto, A., Hosoi, Y., Katsumura, Y., Matsumoto, Y., Morita, A., Shiraishi, K., Miyagawa, K., Igaki, H., & Nakagawa, K. (2010). Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations. Cancer Letters, 293(1), 52-57. https://doi.org/10.1016/j.canlet.2009.12.020