Early-stage primary malignant melanoma of the esophagus detected simultaneously with esophageal squamous cell carcinoma

Makoto Hikage, Takashi Kamei, Fumiyoshi Fujishima, Goh Miyata, Ko Onodera, Hirofumi Ichikawa, Toru Hoshida, Hiroshi Kikuchi, Toru Nakano, Jin Teshima, Motoo Fujita, Hironobu Sasano, Susumu Satomi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Primary malignant melanoma of the esophagus is a rare disease. The majority of patients are diagnosed at an advanced stage, and only a few are detected at an early stage. We herein describe a case of early-stage primary malignant melanoma of the esophagus that was detected simultaneously with early-stage primary esophageal squamous cell carcinoma. Both tumors were detected during esophagogastroduodenoscopy for heartburn. The malignant melanoma tumor was a nevus-like flat-type lesion in the upper thoracic esophagus, and the squamous cell carcinoma was a slightly depressed lesion in the abdominal esophagus. The tumor was resected by thoracoscopic esophagectomy. Histologically, the invasion of both tumors was limited to the mucosal layer, and no lymph node metastasis was detected. Immunohistochemically, the malignant melanoma cells were strongly positive for HMB-45, melan-A, and S-100 protein. The patient has survived without recurrence for 17 months after the operation.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalEsophagus
Volume9
Issue number1
DOIs
Publication statusPublished - 2012 Mar 1

Keywords

  • Early-stage primary malignant melanoma of the esophagus
  • Nevus-like appearance
  • Simultaneous double cancer of the esophagus

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint

Dive into the research topics of 'Early-stage primary malignant melanoma of the esophagus detected simultaneously with esophageal squamous cell carcinoma'. Together they form a unique fingerprint.

Cite this