Early postirradiation changes in Na+ and fluid transport across alveolar epithelium in rats

S. Suzuki, Masafumi Noda, Y. Abe, M. Sugita, S. Ono, T. Tanita, K. Koike, S. Fujimura

Research output: Contribution to journalArticlepeer-review

Abstract

To study changes in Na+ and fluid transport that occur soon after irradiation of the thorax, we used fluid-filled isolated rat lungs. Irradiation 15 Gy of 60Co doubled the fluid absorption rate across the alveolar epithelium within 2 weeks, but fluid absorption had returned to the baseline values by 3 weeks after irradiation. The timing of this change in fluid absorption was parallel to the time course of Na+ escape across alveolar epithelium and the two correlated closely. These data suggest that a dysfunction of alveolar epithelial Na+ transport is involved in the development of pulmonary edema after irradiation of the thorax.

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalJapanese Journal of Thoracic Diseases
Volume35
Issue number2
Publication statusPublished - 1997 Apr 28

Keywords

  • Alveolar epithelium
  • Fluid absorption
  • Na transport
  • Pulmonary edema
  • Radiation pneumonitis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint

Dive into the research topics of 'Early postirradiation changes in Na<sup>+</sup> and fluid transport across alveolar epithelium in rats'. Together they form a unique fingerprint.

Cite this