Early postirradiation changes in Na+ and fluid transport across alveolar epithelium in rats

S. Suzuki, Masafumi Noda, Y. Abe, M. Sugita, S. Ono, T. Tanita, K. Koike, S. Fujimura

Research output: Contribution to journalArticlepeer-review


To study changes in Na+ and fluid transport that occur soon after irradiation of the thorax, we used fluid-filled isolated rat lungs. Irradiation 15 Gy of 60Co doubled the fluid absorption rate across the alveolar epithelium within 2 weeks, but fluid absorption had returned to the baseline values by 3 weeks after irradiation. The timing of this change in fluid absorption was parallel to the time course of Na+ escape across alveolar epithelium and the two correlated closely. These data suggest that a dysfunction of alveolar epithelial Na+ transport is involved in the development of pulmonary edema after irradiation of the thorax.

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalJapanese Journal of Thoracic Diseases
Issue number2
Publication statusPublished - 1997 Apr 28


  • Alveolar epithelium
  • Fluid absorption
  • Na transport
  • Pulmonary edema
  • Radiation pneumonitis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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