Early effects of Lansoprazole orally disintegrating tablets on intragastric pH in CYP2C19 extensive metabolizers

Hatsushi Yamagishi, Tomoyuki Koike, Shuichi Ohara, Toru Horii, Ryousuke Kikuchi, Shigeyuki Kobayashi, Yasuhiko Abe, Katsunori Iijima, Akira Imatani, Kaori Suzuki, Takanori Hishinuma, Junichi Goto, Tooru Shimosegawa

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Aim: To compare rabeprazole (RPZ; 10 mg) with Lansoprazole orally disintegrating tablets (LPZ; 30 mg OD) in terms of antisecretory activity and blood drug concentration after a single dose. Methods: Eight H pylori-negative cytochrome P450 (CYP) 2C19 extensive metabolizers were assigned to receive a single oral dose of RPZ 10 mg or LPZ 30 mg OD. Twelve hour intragastric pH monitoring was performed on the day of treatment. Blood samples were also collected after the administration of each drug. Results: LPZ 30 mg OD induced a significantly earlier rise in blood drug concentration than RPZ 10 mg; consequently, LPZ 30 mg OD induced a significantly earlier rise in median pH in the third and fourth hours of the study. Conclusion: In H pylori-negative CYP2C19 extensive metabolizers, LPZ 30 mg OD induced a significantly faster inhibition of gastric acid secretion than RPZ 10 mg.

Original languageEnglish
Pages (from-to)2049-2054
Number of pages6
JournalWorld Journal of Gastroenterology
Volume14
Issue number13
DOIs
Publication statusPublished - 2008 Apr 7

Keywords

  • Blood drug concentration
  • Cytochrome P450 2C19 extensive metabolizers
  • H pylori-negative
  • Intragastric pH
  • LPZ 30 mg orally disintegrating tablets

ASJC Scopus subject areas

  • Gastroenterology

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