Early death of mice cloned from somatic cells

Narumi Ogonuki; Kimiko Inoue; Yoshie Yamamoto; Yoko Noguchi; Kentaro Tanemura; Osamu Suzuki; Hiroyuki Nakayama; Kunio Doi; Yukiko Ohtomo; Michiko Satoh; Akira Nishida; Atsuo Ogura

doi:10.1038/ng841

Early death of mice cloned from somatic cells

Narumi Ogonuki, Kimiko Inoue, Yoshie Yamamoto, Yoko Noguchi, Kentaro Tanemura, Osamu Suzuki, Hiroyuki Nakayama, Kunio Doi, Yukiko Ohtomo, Michiko Satoh, Akira Nishida, Atsuo Ogura

Research output: Contribution to journal › Article › peer-review

208 Citations (Scopus)

Abstract

Here we report that the lifespan of mice cloned from somatic cells is significantly shorter than that of genotype- and sex-matched controls, most likely due to severe pneumonia and hepatic failure. This finding demonstrates the possibility of long-term deleterious effects of somatic-cell cloning, even after normal birth.

Original language	English
Pages (from-to)	253-254
Number of pages	2
Journal	Nature Genetics
Volume	30
Issue number	3
DOIs	https://doi.org/10.1038/ng841
Publication status	Published - 2002 Mar
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1038/ng841

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title = "Early death of mice cloned from somatic cells",

abstract = "Here we report that the lifespan of mice cloned from somatic cells is significantly shorter than that of genotype- and sex-matched controls, most likely due to severe pneumonia and hepatic failure. This finding demonstrates the possibility of long-term deleterious effects of somatic-cell cloning, even after normal birth.",

author = "Narumi Ogonuki and Kimiko Inoue and Yoshie Yamamoto and Yoko Noguchi and Kentaro Tanemura and Osamu Suzuki and Hiroyuki Nakayama and Kunio Doi and Yukiko Ohtomo and Michiko Satoh and Akira Nishida and Atsuo Ogura",

note = "Funding Information: This work was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology; the Ministry of Health, Labor and Welfare; and the Human Science Foundation of Japan.",

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T1 - Early death of mice cloned from somatic cells

AU - Ogonuki, Narumi

AU - Inoue, Kimiko

AU - Yamamoto, Yoshie

AU - Noguchi, Yoko

AU - Tanemura, Kentaro

AU - Suzuki, Osamu

AU - Nakayama, Hiroyuki

AU - Doi, Kunio

AU - Ohtomo, Yukiko

AU - Satoh, Michiko

AU - Nishida, Akira

AU - Ogura, Atsuo

N1 - Funding Information: This work was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology; the Ministry of Health, Labor and Welfare; and the Human Science Foundation of Japan.

PY - 2002/3

Y1 - 2002/3

N2 - Here we report that the lifespan of mice cloned from somatic cells is significantly shorter than that of genotype- and sex-matched controls, most likely due to severe pneumonia and hepatic failure. This finding demonstrates the possibility of long-term deleterious effects of somatic-cell cloning, even after normal birth.

AB - Here we report that the lifespan of mice cloned from somatic cells is significantly shorter than that of genotype- and sex-matched controls, most likely due to severe pneumonia and hepatic failure. This finding demonstrates the possibility of long-term deleterious effects of somatic-cell cloning, even after normal birth.

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Early death of mice cloned from somatic cells

Abstract

ASJC Scopus subject areas

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