Early appearance and activation of natural killer cells in tumor‐infiltrating lymphoid cells during tumor development

Shin Kurosawa, Goro Matsuzaki, Mamoru Harada, Takashi Ando, Kikuo Nomoto

    Research output: Contribution to journalArticlepeer-review

    30 Citations (Scopus)

    Abstract

    We investigated NK cell infiltration into tumor developing lesions at early stage of tumor development after intraperitoneal inoculation of 3LL lung carcinoma into syngeneic C57BL/6 mice. Natural killer (NK) cells, which were detected by anti‐NK 1.1 monoclonal antibody (mAb), remarkably increased in number in tumor‐developing lesions (peritoneal cavity) as early as day 3 after inoculation of 3LL. The tumor‐infiltrating NK cells from 3LL‐inoculated mice produced a high level of interferon‐γ by co‐culture with 3LL and showed enhanced cytotoxic activities against both NK‐sensitive (YAC‐1) and NK‐resistant (3LL and P815) tumors. Furthermore, mice depleted of NK cells by injection of anti‐NK 1.1 mAb or antiasialo GM1 antibody showed shorter survival times after intraperitoneal inoculation of 3LL when compared with control mice. These results suggest that NK cells infiltrate the tumor‐developing lesion at an early stage and may participate in the early protection against tumors through production of a high amount of interferon‐γ and enhanced cytotoxicity at tumor‐bearing sites.

    Original languageEnglish
    Pages (from-to)1029-1033
    Number of pages5
    JournalEuropean Journal of Immunology
    Volume23
    Issue number5
    DOIs
    Publication statusPublished - 1993 May

    Keywords

    • Natural killer cells
    • Tumor
    • Tumor‐infiltrating lymphocytes

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

    Fingerprint Dive into the research topics of 'Early appearance and activation of natural killer cells in tumor‐infiltrating lymphoid cells during tumor development'. Together they form a unique fingerprint.

    Cite this