Dystonin deficiency reduces taste buds and fungiform papillae in the anterior part of the tongue

H. Ichikawa, R. Terayama, T. Yamaai, Y. De Repentigny, R. Kothary, T. Sugimoto

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The anterior part of the tongue was examined in wild type and dystonia musculorum mice to assess the effect of dystonin loss on fungiform papillae. In the mutant mouse, the density of fungiform papillae and their taste buds was severely decreased when compared to wild type littermates (papilla, 67% reduction; taste bud, 77% reduction). The mutation also reduced the size of these papillae (17% reduction) and taste buds (29% reduction). In addition, immunohistochemical analysis demonstrated that the dystonin mutation reduced the number of PGP 9.5 and calbindin D28k-containing nerve fibers in fungiform papillae. These data together suggest that dystonin is required for the innervation and development of fungiform papillae and taste buds.

Original languageEnglish
Pages (from-to)142-146
Number of pages5
JournalBrain research
Volume1129
Issue number1
DOIs
Publication statusPublished - 2007 Jan 19
Externally publishedYes

Keywords

  • Calbindin D-28k
  • Dystonin
  • Fungiform papilla
  • Immunohistochemistry
  • Mutant mouse
  • PGP 9.5
  • Taste bud

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Dystonin deficiency reduces taste buds and fungiform papillae in the anterior part of the tongue'. Together they form a unique fingerprint.

  • Cite this