A 32-year-old man had dysgenesis of the corpus callosum associated with iris nevi and conjunctival malignant melanoma. Iris lesions revealed intrastromal proliferation of melanocytes accompanied by surface plaque. Epithelioid and spindle cells with pigmentation, positive for the melanoma marker HMB-45 and S-100 protein, were observed in the conjunctival lesion by histologic examination. These findings may suggest an underlying neoplastic potential of melanocytes.
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