Dynamics of memory-guided choice behavior in Drosophila

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Memory retrieval requires both accuracy and speed. Olfactory learning of the fruit fly Drosophila melanogaster serves as a powerful model system to identify molecular and neuronal substrates of memory and memory-guided behavior. The behavioral expression of olfactory memory has traditionally been tested as a conditioned odor response in a simple T-maze, which measures the result, but not the speed, of odor choice. Here, we developed multiplexed T-mazes that allow video recording of the choice behavior. Automatic fly counting in each arm of the maze visualizes choice dynamics. Using this setup, we show that the transient blockade of serotonergic neurons slows down the choice, while leaving the eventual choice intact. In contrast, activation of the same neurons impairs the eventual performance leaving the choice speed unchanged. Our new apparatus contributes to elucidating how the speed and the accuracy of memory retrieval are implemented in the fly brain.

Original languageEnglish
Pages (from-to)346-357
Number of pages12
JournalProceedings of the Japan Academy Series B: Physical and Biological Sciences
Volume92
Issue number8
DOIs
Publication statusPublished - 2016

Keywords

  • Choice speed
  • Olfactory learning
  • Serotonin
  • Tool development

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Physics and Astronomy(all)

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