Dynamical Features of Thermoregulatory Model of Sleep Control

Mitsuyuki Nakao, Mitsuaki Yamamoto, Dennis McGinty, Ronald Szymusiak

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

We have developed a quantitative model of human sleep-wake rhythms based on a thermoregulatory feedback control mechanism modulated by two circadian oscillators. Homeostatic features of sleep regulation are realized through the heat memory which represents the history of the masking process associated with sleep-wake cycles: heat load during wake and heat loss during sleep. Simulations under entrained conditions showed that the model closely mimicks well-known features of human sleep-wake rhythm, and that the homeostatic and the oscillatory aspects of the human circadian system are successfully integrated in our model. In this paper, parameter dependency of the model behavior is studied by simulations. Because of its physiology-based structure, the parameter dependency could show the possible underlying mechanism for the typical features of human sleep-wake rhythm. In addition, the model stability is analyzed by the linear system theory and the simulations, which establishes the stability condition and suggests that the presented simulation results are basically stable. These results are informative to apply our model to actual data of sleep-wake rhythms, and to interpret them from the physiological point of view.

Original languageEnglish
Pages (from-to)311-326
Number of pages16
JournalJapanese Journal of Physiology
Volume45
Issue number2
DOIs
Publication statusPublished - 1995

Keywords

  • parameter dependency
  • perturbations
  • stability
  • thermoregulatory model of sleep

ASJC Scopus subject areas

  • Physiology

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