Dynamic-enhanced MRI predicts metastatic potential of invasive ductal breast cancer

Takeshi Nagashima, Masato Suzuki, Hiroshi Yagata, Hideyuki Hashimoto, Tomotane Shishikura, Nobuhiro Imanaka, Takuya Ueda, Masaru Miyazaki

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Dynamic magnetic resonance imaging (MR]) has improved the detection of breast malignancies. The method is based on estimating the velocity of contrast enhancement taking into account increased angiogenesis in tumor. Microvessel density correlates with breast carcinoma metastasis. Thus, we hypothesized that contrast enhancement on MRI correlates with metastasis in breast cancer patients. The present study attempts to clarify the quantitative assessment of dynamic data, and examines the correlation between MRI enhancement and breast carcinoma metastasis. Methods: The subjects consisted of 31 patients with invasive ductal breast cancer. Twenty patients were disease free for five years (group A), and eleven patients suffered from metastatic disease at distant sites concurrently or postoperatively (group B). Dynamic MRI was performed preoperatively using a 1.5T system in all cases. Using the dynamic data, the signal intensity (SI) ratio and SI index were determined and analyzed retrospectively taking into account the presence of distant metastases. Results: The values of the SI ratio were 2.2 -+ 0.7 in group A and 2.3 -+ 0.4 in group B, respectively, with no significant difference seen between the groups. The SI index value was significantly higher in group B (28.5 -+ 32.8) than in group A (10.3 -+ 5.5, p < 0.05). Conclusions: The current series suggests that the SI index could distinguish patients with high risk of distant metastasis from disease free patients, preoperatively. If a suitable borderline value were established, the quantitative dynamic parameter determined by MR] may be useful for predicting the prognosis of breast cancer patients. Breast Cancer 9:226-230, 2002.

Original languageEnglish
Pages (from-to)226-230
Number of pages5
JournalBreast Cancer
Volume9
Issue number3
DOIs
Publication statusPublished - 2002 Jul

Keywords

  • Breast neoplasms
  • Carcinoma
  • Dynamic imaging
  • MRI
  • Metastasis

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)

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  • Cite this

    Nagashima, T., Suzuki, M., Yagata, H., Hashimoto, H., Shishikura, T., Imanaka, N., Ueda, T., & Miyazaki, M. (2002). Dynamic-enhanced MRI predicts metastatic potential of invasive ductal breast cancer. Breast Cancer, 9(3), 226-230. https://doi.org/10.1007/BF02967594