Dynamic changes in near-infrared spectroscopy (NIRS) findings in first-episode schizophrenia: a case report

Tsuyoshi Hatakeyama, Yasuto Kunii, Itaru Miura, Shuntaro Itagaki, Soichi Kono, Tetsuya Shiga, Sachie Oshima, Keiko Nozaki, Rieko Suzuki, Hirooki Yabe

Research output: Contribution to journalArticle

Abstract

The clinical course of schizophrenia is characterized by recurrence and chronicity and has a large burden on society. Nevertheless, diagnosis of schizophrenia is based only on distinctive symptoms and the disease course. Near-infrared spectroscopy (NIRS) is a useful method for measuring changes in the hemoglobin concentration in the cortical surface area and reflects brain function. We measured NIRS four times during the clinical course in a patient with first-episode schizophrenia.A 17-year-old woman admitted to our hospital because of hallucinations, delusions and appetite loss. After treatment with low-dose antipsychotics, NIRS findings showed a prompt increase in the cerebral blood volume in the frontal region. On the basis of the clinical course of this patient, we introduce a new point of view, namely, that NIRS findings may be useful as a state marker that indicates the severity of schizophrenia in some cases.

Original languageEnglish
Pages (from-to)28-31
Number of pages4
JournalFukushima journal of medical science
Volume63
Issue number1
DOIs
Publication statusPublished - 2017 Apr 28

Keywords

  • biomarker
  • homovanillic acid
  • near-infrared spectroscopy
  • schizophrenia
  • state marker

ASJC Scopus subject areas

  • Medicine(all)

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    Hatakeyama, T., Kunii, Y., Miura, I., Itagaki, S., Kono, S., Shiga, T., Oshima, S., Nozaki, K., Suzuki, R., & Yabe, H. (2017). Dynamic changes in near-infrared spectroscopy (NIRS) findings in first-episode schizophrenia: a case report. Fukushima journal of medical science, 63(1), 28-31. https://doi.org/10.5387/fms.2016-22