Dynamic changes in magnetic resonance imaging appearance of dysembryoplastic neuroepithelial tumor with or without malignant transformation: Report of 2 cases

Yui Mano, Toshihiro Kumabe, Ichiyo Shibahara, Ryuta Saito, Yukihiko Sonoda, Mika Watanabe, Teiji Tominaga

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Dysembryoplastic neuroepithelial tumors (DNETs) have conventionally been regarded as benign and stable tumors and considered curable with surgery without adjunctive therapy. Recently, recurrent DNETs with or without malignant transformation have been described. The authors report 2 unusual cases of DNET: 1) an enlarging lesion that developed an enhancing component over the natural course of 4 years, and 2) a recurrent DNET that developed an enhancing component 10-11 years after gross-total resection. The patient in the first case was treated with subtotal resection and adjuvant radiochemotherapy; histological examination of the tumor led to the diagnosis of DNET, WHO Grade I, for the nonenhancing component and anaplastic oligodendroglioma, WHO Grade III, for the enhancing component. The patient in the second case was treated with repeat gross-total resection; the original tumor had been histologically diagnosed as DNET, and the nonenhancing and enhancing components of the recurrent tumor were diagnosed as simple and complex forms of DNET, respectively. These and previous reports suggest an aggressive subtype of DNETs. If follow-up MRI reveals progressive behavior, resection should be performed without delay. Additional radiochemotherapy is needed if the histological diagnosis demonstrates malignant transformation.

Original languageEnglish
Pages (from-to)518-525
Number of pages8
JournalJournal of Neurosurgery: Pediatrics
Volume11
Issue number5
DOIs
Publication statusPublished - 2013 May 1

Keywords

  • Dysembryoplastic neuroepithelial tumor
  • Magnetic resonance imaging
  • Malignant transformation
  • Oncology
  • Recurrence

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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