Dynamic assembly/disassembly processes of photoresponsive DNA origami nanostructures directly visualized on a lipid membrane surface

Yuki Suzuki, Masayuki Endo, Yangyang Yang, Hiroshi Sugiyama

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Here, we report the direct visualization of the assembly/disassembly processes of photoresponsive DNA origami nanostructures which can be placed on a lipid bilayer surface. The observation relies on controlled interactions between the bilayer components and cholesterol moieties introduced to the hexagonal origami structures, one of whose outer edges carries Azo-ODNs. The bilayer-placed hexagonal dimer was disassembled into monomer units by UV irradiation, and reversibly assembled again during visible light irradiation. These dynamic processes were directly monitored with high-speed atomic force microscopy. The successful application of our approach should facilitate studies of interactive and functional behaviors of various DNA nanostructures.

Original languageEnglish
Pages (from-to)1714-1717
Number of pages4
JournalJournal of the American Chemical Society
Volume136
Issue number5
DOIs
Publication statusPublished - 2014 Feb 5

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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