Dual-time point scanning of integrated FDG PET/CT for the evaluation of mediastinal and hilar lymph nodes in non-small cell lung cancer diagnosed as operable by contrast-enhanced CT

Takami Kasai, Ken Motoori, Takuro Horikoshi, Katsuhiro Uchiyam, Kazuhiro Yasufuku, Yuichi Takiguchi, Fumiaki Takahashi, Yoshio Kuniyasu, Hisao Ito

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Purpose: To evaluate whether dual-time point scanning with integrated fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography and computed tomography (PET/CT) is useful for evaluation of mediastinal and hilar lymph nodes in non-small cell lung cancer diagnosed as operable by contrast-enhanced CT. Materials and methods: PET/CT data and pathological findings of 560 nodal stations in 129 patients with pathologically proven non-small cell lung cancer diagnosed as operable by contrast-enhanced CT were reviewed retrospectively. Standardized uptake values (SUVs) on early scans (SUVe) 1 h, and on delayed scans (SUVd) 2 h after FDG injection of each nodal station were measured. Retention index (RI) (%) was calculated by subtracting SUVe from SUVd and dividing by SUVe. Logistic regression analysis was performed with seven kinds of models, consisting of (1) SUVe, (2) SUVd, (3) RI, (4) SUVe and SUVd, (5) SUVe and RI, (6) SUVd and RI, and (7) SUVe, SUVd and RI. The seven derived modelswere compared by receiveroperating characteristic (ROC) analysis. k-Fold cross-validation was performed with k values of 5 and 10. p < 0.05 was considered statistically significant. Results: Model (1) including the term of SUVe showed the largest area under the ROC curve among the seven models. The cut-off probability of metastasis of 3.5% with SUVe of 2.5 revealed a sensitivity of 78% and a specificity of 81% on ROC analysis, and approximately 60% and 80% on k-fold cross-validation. Conclusion: Single scanning of PET/CT is sufficiently useful for evaluating mediastinal and hilar nodes for metastasis.

Original languageEnglish
Pages (from-to)143-146
Number of pages4
JournalEuropean Journal of Radiology
Volume75
Issue number2
DOIs
Publication statusPublished - 2010 Jan 1
Externally publishedYes

Keywords

  • Dual-time point scanning
  • Integrated FDG PET/CT
  • Lymph node metastasis
  • Non-small cell lung cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Dual-time point scanning of integrated FDG PET/CT for the evaluation of mediastinal and hilar lymph nodes in non-small cell lung cancer diagnosed as operable by contrast-enhanced CT'. Together they form a unique fingerprint.

  • Cite this