Dual-function probe to detect protease activity for fluorescence measurement and 19F MRI

Shin Mizukami, Rika Takikawa, Fuminori Sugihara, Masahiro Shirakawa, Kazuya Kikuchi

Research output: Contribution to journalArticlepeer-review

110 Citations (Scopus)

Abstract

Dynamic duo: Magnetic resonance imaging (MRI) can visualize deep regions of living bodies, whereas fluorescence measurement offers excellent sensitivity. These methods thus offer signal enhancement potential for detecting enzyme activities. A dual-mode off/on probe to detect caspase-3 activity by fluorescence and 19F MRI is presented.

Original languageEnglish
Pages (from-to)3641-3643
Number of pages3
JournalAngewandte Chemie - International Edition
Volume48
Issue number20
DOIs
Publication statusPublished - 2009 May 4
Externally publishedYes

Keywords

  • Fluorescence
  • Magnetic resonance imaging
  • Molecular imaging
  • Multimodal probe
  • Proteases

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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