Dual effects of the substrate and pterins on the kinetics of CO binding to neuronal nitric oxide synthase: A laser flash photolysis study

Simona N. Bengea, Yasuyuki Araki, Osamu Ito, Jotaro Igarashi, Hirofumi Kurokawa, Toru Shimizu

Research output: Contribution to journalArticlepeer-review

Abstract

Derivatives of pterin, an important cofactor for neuronal nitric oxide synthase, markedly changed the kinetics of CO binding to the enzyme-bound heme. In the absence of the substrate, L-Arg, CO binding was dependent on the CO concentration for pterin complexes, whereas in the presence of L-Arg, it became CO-independent for most pterin complexes. This suggests dual effects of substrate and pterin binding on the kinetics and access of CO to the ligand channel.

Original languageEnglish
Pages (from-to)752-753
Number of pages2
JournalChemistry Letters
Volume34
Issue number6
DOIs
Publication statusPublished - 2005 Jun 5

ASJC Scopus subject areas

  • Chemistry(all)

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