DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro.

Tatsuo Hata, Takenori Ogawa, Tada aki Yokoyama, Shinichi Fukushige, Akira Horii, Toru Furukawa

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

TP53-inducible genes play crucial roles from many biological aspects including cell cycle control, DNA repair, and apoptosis. Herein we report the identification and characterization of a novel TP53-inducible gene, DSCP1 (damage stimulated cytoplasmic protein 1), localized at 17q11. The gene was expressed ubiquitously in normal adult tissues; its protein product was localized mainly in the cytoplasm with anchoring on unknown subcellular structures. Exogenous expression of TP53 induced expression of DSCP1, but more interestingly, DSCP1 was induced by strong genotoxic stresses not only in TP53-maintaining cells but also in TP53-dysfunctioning cells, although the induction was much more efficient in the former than in the latter. In cultured cancer cells, the basal expression level appeared to depend on the functional status of TP53. Moreover, exogenous overexpression of DSCP1 retarded cancer cell growth in vitro. These results indicate that DSCP1 is a stress-inducible gene in both a TP53 dependent and independent manner and that its protein product can inhibit cancer cell growth.

Original languageEnglish
Pages (from-to)513-520
Number of pages8
JournalInternational journal of oncology
Volume24
Issue number3
Publication statusPublished - 2004 Mar

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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