Drug Prescriptions for Children With ADHD in Japan: A Study Based on Health Insurance Claims Data Between 2005 and 2015

Makiko Yoshida, Taku Obara, Saya Kikuchi, Michihiro Satoh, Yoshihiko Morikawa, Nobuhiro Ooba, Hiroaki Yamaguchi, Nariyasu Mano

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Objective: The aim of this study is to investigate the trend of prescription drugs for children with ADHD in Japan. Method: Using health insurance claims data of 3,672,951 people between January 2005 and December 2015, we investigated the trend of prescription drugs for 7,856 children with ADHD. Results: After approval in 2007, the proportion of prescriptions for methylphenidate-osmotic-controlled release oral delivery system tablets was 31.4% in 2009 (adjusted odds ratio [AOR] = 2.72; 95% confidence interval [CI] = [2.12, 3.51]) and reached a plateau approximately after 2009 (AOR = 0.96; 95% CI = [0.94, 0.98]). The proportion of prescriptions for atomoxetine increased from 6.1% in 2008 to 21.8% in 2014 (AOR = 1.12; 95% CI = [1.13, 1.18]). The proportion of prescriptions for aripiprazole and ramelteon increased (all trend p <.001). Conclusion: Prescriptions of drugs for children with ADHD have changed. We need to monitor the safety of ADHD medications among children with ADHD.

Original languageEnglish
Pages (from-to)175-191
Number of pages17
JournalJournal of Attention Disorders
Volume24
Issue number2
DOIs
Publication statusPublished - 2020 Jan 1

Keywords

  • ADHD
  • children
  • proportion of prescription

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Clinical Psychology

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