Abstract
The double functionalization of styrenes through Cu-mediated assisted tandem catalysis was developed. The reaction was initiated by Cu-catalyzed aziridination and the subsequent nucleophilic ring-opening, which was triggered by the addition of (NH 4 ) 2 S 2 O 8 as an oxidant of Cu-catalyst to form a variety of C–C and C–X bonds. The expansion to three contiguous catalytic cycles led to the synthesis of functionalized indolines by one-pot operation.
Original language | English |
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Pages (from-to) | 2056-2060 |
Number of pages | 5 |
Journal | European Journal of Organic Chemistry |
Volume | 2019 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2019 Mar 14 |
Keywords
- Cu-catalysis
- Double functionalization
- Indolines
- Spirocycle
- Tandem catalysis
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry