Double-blind comparative study on cefdinir and cefaclor in bacterial pneumonia

Kohei Hara; Masaki Hirota; Shigeru Kohno; Yasumasa Doitsu; Kazuo Sasayama; Akira Yasuoka; Hiroshi Yamada; Shigefumi Maesaki; Sadahiro Asai; Mitsuo Kaku; Hideo Mashimoto; Toshiaki Hayashi; Kiyoyasu Fukushima; Naofumi Suyama; Osamu Sakito; Yoshikazu Kawakami; Etsuro Yamaguchi; Nozomu Okazaki; Hiroshi Yamamoto; Ikuhiro Tsuneta; Akira Saito; Masumi Tomizawa; Ichiro Nakayama; Kazuo Takebe; Toyokazu Tamura; Ken ichi Imamura; Masao Tamura; Kazuki Konishi; Takashi Mohri; Kazuo Obara; Yoshiaki Mori; Takashi Ito; Hitoshi Kobayashi; Tsukasa Yoshida; Ken ichi Takeuchi; Toshiharu Ito; Hiromi Kanayama; Kiyoshi Konno; Kotaro Oizumi; Akira Watanabe; Seiichi Aonuma; Yushi Nakai; Jun ichi Saito; Kazuo Sato; Tsuneo Sayama; Tohru Kanaya; Kohsaku Nagai; Izumi Hayashi; Masataka Katsu; Kohichiro Asano; Junzaburo Kabe; Kohichiro Kudo; Kihachiro Shimizu; Jun ichi Katahira; Osamu Sakai; Jingoro Shimada; Kohya Shiba; Atsushi Saito; Kaoru Shimada; Kazufuto Fukaya; Yasuyuki Sano; Yasufumi Miyamoto; Hiroyuki Kobayashi; Hiroshi Oshitani; Hiroaki Takeda; Fumio Matsumoto; Iwao Sakurai; Toshio Hojo; Shoichiro Irimajiri; Mitsuo Obana; Shigeki Odagiri; Kaneo Suzuki; Kou Murohashi; Teruaki Yoshioka; Izumi Koyama; Takashi Ogura; Norio Kikuchi; Tatsuo Kawashima; Osamu Sekine; Nobuki Aoki; Masaaki Arakawa; Koichi Wada; Masanaga Takato; Shigeyuki Hoshino; Toshihiko Takeuchi; Masahito Kato; Yoshimitsu Hayashi; Hidekazu Hanaki; Go Ito; Sakae Kan; Fumio Miki; Nobuhiro Narita; Masayoshi Sawaki; Keiichi Mikasa; Rinzo Soejima; Jiro Okimoto; Yoshihisa Nakagawa; Kuninori Tsukiyama; Toshiharu Matsushima; Masayoshi Kawanishi; Yoshiro Sayvae; Kenji Kohno; Atsushi Takita; Takatoshi Yamane; Michio Fukuma; Keizo Matsumoto; Hirofumi Tanaka; Tsuyoshi Nagatake; Masaru Nasu; Tohru Yamazaki; Jun Goto; Hideaki Shigeno; Takayoshi Tashiro; Atsushi Saito; Yuei Irabu; Akira Sakuma; Keizo Yamaguchi; Kazuyuki Sugahara; Junichi Matsuda; Chikako Mochida; Chieko Hayashi; Yuji Migita

doi:10.11250/chemotherapy1953.37.Supplement2_634

Double-blind comparative study on cefdinir and cefaclor in bacterial pneumonia

Kohei Hara, Masaki Hirota, Shigeru Kohno, Yasumasa Doitsu, Kazuo Sasayama, Akira Yasuoka, Hiroshi Yamada, Shigefumi Maesaki, Sadahiro Asai, Mitsuo Kaku, Hideo Mashimoto, Toshiaki Hayashi, Kiyoyasu Fukushima, Naofumi Suyama, Osamu Sakito, Yoshikazu Kawakami, Etsuro Yamaguchi, Nozomu Okazaki, Hiroshi Yamamoto, Ikuhiro TsunetaAkira Saito, Masumi Tomizawa, Ichiro Nakayama, Kazuo Takebe, Toyokazu Tamura, Ken ichi Imamura, Masao Tamura, Kazuki Konishi, Takashi Mohri, Kazuo Obara, Yoshiaki Mori, Takashi Ito, Hitoshi Kobayashi, Tsukasa Yoshida, Ken ichi Takeuchi, Toshiharu Ito, Hiromi Kanayama, Kiyoshi Konno, Kotaro Oizumi, Akira Watanabe, Seiichi Aonuma, Yushi Nakai, Jun ichi Saito, Kazuo Sato, Tsuneo Sayama, Tohru Kanaya, Kohsaku Nagai, Izumi Hayashi, Masataka Katsu, Kohichiro Asano, Junzaburo Kabe, Kohichiro Kudo, Kihachiro Shimizu, Jun ichi Katahira, Osamu Sakai, Jingoro Shimada, Kohya Shiba, Atsushi Saito, Kaoru Shimada, Kazufuto Fukaya, Yasuyuki Sano, Yasufumi Miyamoto, Hiroyuki Kobayashi, Hiroshi Oshitani, Hiroaki Takeda, Fumio Matsumoto, Iwao Sakurai, Toshio Hojo, Shoichiro Irimajiri, Mitsuo Obana, Shigeki Odagiri, Kaneo Suzuki, Kou Murohashi, Teruaki Yoshioka, Izumi Koyama, Takashi Ogura, Norio Kikuchi, Tatsuo Kawashima, Osamu Sekine, Nobuki Aoki, Masaaki Arakawa, Koichi Wada, Masanaga Takato, Shigeyuki Hoshino, Toshihiko Takeuchi, Masahito Kato, Yoshimitsu Hayashi, Hidekazu Hanaki, Go Ito, Sakae Kan, Fumio Miki, Nobuhiro Narita, Masayoshi Sawaki, Keiichi Mikasa, Rinzo Soejima, Jiro Okimoto, Yoshihisa Nakagawa, Kuninori Tsukiyama, Toshiharu Matsushima, Masayoshi Kawanishi, Yoshiro Sayvae, Kenji Kohno, Atsushi Takita, Takatoshi Yamane, Michio Fukuma, Keizo Matsumoto, Hirofumi Tanaka, Tsuyoshi Nagatake, Masaru Nasu, Tohru Yamazaki, Jun Goto, Hideaki Shigeno, Takayoshi Tashiro, Atsushi Saito, Yuei Irabu, Akira Sakuma, Keizo Yamaguchi, Kazuyuki Sugahara, Junichi Matsuda, Chikako Mochida, Chieko Hayashi, Yuji Migita

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

We evaluated the efficacy, safety, and usefulness of cefdinir (CFDN), a new oral cephem, in bacterial pneumonia by the multicenter double-blind comparative method using cefaclor (CCL) as a control drug. The dosage was 100 mg of CFDN t.i.d. and 500 mg of CCL t.i.d. for 14 days in principle. 1. The clinical efficacy rate judged by committee was 88.9% for CFDN and 89.9% for CCL. There was no significant difference between the two drugs. 2. In the evaluation of bacteriological effect, the eradication rate was 86.7% and 88.9% in patients given CFDN and CCL respectively. There was no significant difference between the two drugs. 3. There were no significant differences between the two drugs in the improvement rate of clinical symptoms and laboratory parameters. 4. The incidence of side effects was 4.9% in the CFDN group and 3.1% in the CCL group. The incidence of abnormal findings was 20.2% in the CFDN group and 29.5% in the CCL group. There were no significant differences between the two drugs in incidence of side effects or abnormal laboratory findings. 5. The usefulness rate was 83.8% for CFDN and 89.6% for CCL. There was no significant difference between the two drugs. The clinical efficacy, safety, and usefulness of CFDN 100mg t.i.d. were as high as those of CCL 500mg t. i. d. It is concluded that CFDN is an oral antibiotic which is clinically useful in the treatment of bacterial pneumonia.

Original language	English
Pages (from-to)	634-659
Number of pages	26
Journal	Chemotherapy
Volume	37
DOIs	https://doi.org/10.11250/chemotherapy1953.37.Supplement2_634
Publication status	Published - 1989
Externally published	Yes

Keywords

Cefdinir

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology
Drug Discovery
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.11250/chemotherapy1953.37.Supplement2_634

Cite this

Hara, K., Hirota, M., Kohno, S., Doitsu, Y., Sasayama, K., Yasuoka, A., Yamada, H., Maesaki, S., Asai, S., Kaku, M., Mashimoto, H., Hayashi, T., Fukushima, K., Suyama, N., Sakito, O., Kawakami, Y., Yamaguchi, E., Okazaki, N., Yamamoto, H., ... Migita, Y. (1989). Double-blind comparative study on cefdinir and cefaclor in bacterial pneumonia. Chemotherapy, 37, 634-659. https://doi.org/10.11250/chemotherapy1953.37.Supplement2_634

Double-blind comparative study on cefdinir and cefaclor in bacterial pneumonia. / Hara, Kohei; Hirota, Masaki; Kohno, Shigeru; Doitsu, Yasumasa; Sasayama, Kazuo; Yasuoka, Akira; Yamada, Hiroshi; Maesaki, Shigefumi; Asai, Sadahiro; Kaku, Mitsuo; Mashimoto, Hideo; Hayashi, Toshiaki; Fukushima, Kiyoyasu; Suyama, Naofumi; Sakito, Osamu; Kawakami, Yoshikazu; Yamaguchi, Etsuro; Okazaki, Nozomu; Yamamoto, Hiroshi; Tsuneta, Ikuhiro; Saito, Akira; Tomizawa, Masumi; Nakayama, Ichiro; Takebe, Kazuo; Tamura, Toyokazu; Imamura, Ken ichi; Tamura, Masao; Konishi, Kazuki; Mohri, Takashi; Obara, Kazuo; Mori, Yoshiaki; Ito, Takashi; Kobayashi, Hitoshi; Yoshida, Tsukasa; Takeuchi, Ken ichi; Ito, Toshiharu; Kanayama, Hiromi; Konno, Kiyoshi; Oizumi, Kotaro; Watanabe, Akira; Aonuma, Seiichi; Nakai, Yushi; Saito, Jun ichi; Sato, Kazuo; Sayama, Tsuneo; Kanaya, Tohru; Nagai, Kohsaku; Hayashi, Izumi; Katsu, Masataka; Asano, Kohichiro; Kabe, Junzaburo; Kudo, Kohichiro; Shimizu, Kihachiro; Katahira, Jun ichi; Sakai, Osamu; Shimada, Jingoro; Shiba, Kohya; Saito, Atsushi; Shimada, Kaoru; Fukaya, Kazufuto; Sano, Yasuyuki; Miyamoto, Yasufumi; Kobayashi, Hiroyuki; Oshitani, Hiroshi; Takeda, Hiroaki; Matsumoto, Fumio; Sakurai, Iwao; Hojo, Toshio; Irimajiri, Shoichiro; Obana, Mitsuo; Odagiri, Shigeki; Suzuki, Kaneo; Murohashi, Kou; Yoshioka, Teruaki; Koyama, Izumi; Ogura, Takashi; Kikuchi, Norio; Kawashima, Tatsuo; Sekine, Osamu; Aoki, Nobuki; Arakawa, Masaaki; Wada, Koichi; Takato, Masanaga; Hoshino, Shigeyuki; Takeuchi, Toshihiko; Kato, Masahito; Hayashi, Yoshimitsu; Hanaki, Hidekazu; Ito, Go; Kan, Sakae; Miki, Fumio; Narita, Nobuhiro; Sawaki, Masayoshi; Mikasa, Keiichi; Soejima, Rinzo; Okimoto, Jiro; Nakagawa, Yoshihisa; Tsukiyama, Kuninori; Matsushima, Toshiharu; Kawanishi, Masayoshi; Sayvae, Yoshiro; Kohno, Kenji; Takita, Atsushi; Yamane, Takatoshi; Fukuma, Michio; Matsumoto, Keizo; Tanaka, Hirofumi; Nagatake, Tsuyoshi; Nasu, Masaru; Yamazaki, Tohru; Goto, Jun; Shigeno, Hideaki; Tashiro, Takayoshi; Saito, Atsushi; Irabu, Yuei; Sakuma, Akira; Yamaguchi, Keizo; Sugahara, Kazuyuki; Matsuda, Junichi; Mochida, Chikako; Hayashi, Chieko; Migita, Yuji.

In: Chemotherapy, Vol. 37, 1989, p. 634-659.

Research output: Contribution to journal › Article › peer-review

Hara, K, Hirota, M, Kohno, S, Doitsu, Y, Sasayama, K, Yasuoka, A, Yamada, H, Maesaki, S, Asai, S, Kaku, M, Mashimoto, H, Hayashi, T, Fukushima, K, Suyama, N, Sakito, O, Kawakami, Y, Yamaguchi, E, Okazaki, N, Yamamoto, H, Tsuneta, I, Saito, A, Tomizawa, M, Nakayama, I, Takebe, K, Tamura, T, Imamura, KI, Tamura, M, Konishi, K, Mohri, T, Obara, K, Mori, Y, Ito, T, Kobayashi, H, Yoshida, T, Takeuchi, KI, Ito, T, Kanayama, H, Konno, K, Oizumi, K, Watanabe, A, Aonuma, S, Nakai, Y, Saito, JI, Sato, K, Sayama, T, Kanaya, T, Nagai, K, Hayashi, I, Katsu, M, Asano, K, Kabe, J, Kudo, K, Shimizu, K, Katahira, JI, Sakai, O, Shimada, J, Shiba, K, Saito, A, Shimada, K, Fukaya, K, Sano, Y, Miyamoto, Y, Kobayashi, H, Oshitani, H, Takeda, H, Matsumoto, F, Sakurai, I, Hojo, T, Irimajiri, S, Obana, M, Odagiri, S, Suzuki, K, Murohashi, K, Yoshioka, T, Koyama, I, Ogura, T, Kikuchi, N, Kawashima, T, Sekine, O, Aoki, N, Arakawa, M, Wada, K, Takato, M, Hoshino, S, Takeuchi, T, Kato, M, Hayashi, Y, Hanaki, H, Ito, G, Kan, S, Miki, F, Narita, N, Sawaki, M, Mikasa, K, Soejima, R, Okimoto, J, Nakagawa, Y, Tsukiyama, K, Matsushima, T, Kawanishi, M, Sayvae, Y, Kohno, K, Takita, A, Yamane, T, Fukuma, M, Matsumoto, K, Tanaka, H, Nagatake, T, Nasu, M, Yamazaki, T, Goto, J, Shigeno, H, Tashiro, T, Saito, A, Irabu, Y, Sakuma, A, Yamaguchi, K, Sugahara, K, Matsuda, J, Mochida, C, Hayashi, C & Migita, Y 1989, 'Double-blind comparative study on cefdinir and cefaclor in bacterial pneumonia', Chemotherapy, vol. 37, pp. 634-659. https://doi.org/10.11250/chemotherapy1953.37.Supplement2_634

Hara, Kohei ; Hirota, Masaki ; Kohno, Shigeru ; Doitsu, Yasumasa ; Sasayama, Kazuo ; Yasuoka, Akira ; Yamada, Hiroshi ; Maesaki, Shigefumi ; Asai, Sadahiro ; Kaku, Mitsuo ; Mashimoto, Hideo ; Hayashi, Toshiaki ; Fukushima, Kiyoyasu ; Suyama, Naofumi ; Sakito, Osamu ; Kawakami, Yoshikazu ; Yamaguchi, Etsuro ; Okazaki, Nozomu ; Yamamoto, Hiroshi ; Tsuneta, Ikuhiro ; Saito, Akira ; Tomizawa, Masumi ; Nakayama, Ichiro ; Takebe, Kazuo ; Tamura, Toyokazu ; Imamura, Ken ichi ; Tamura, Masao ; Konishi, Kazuki ; Mohri, Takashi ; Obara, Kazuo ; Mori, Yoshiaki ; Ito, Takashi ; Kobayashi, Hitoshi ; Yoshida, Tsukasa ; Takeuchi, Ken ichi ; Ito, Toshiharu ; Kanayama, Hiromi ; Konno, Kiyoshi ; Oizumi, Kotaro ; Watanabe, Akira ; Aonuma, Seiichi ; Nakai, Yushi ; Saito, Jun ichi ; Sato, Kazuo ; Sayama, Tsuneo ; Kanaya, Tohru ; Nagai, Kohsaku ; Hayashi, Izumi ; Katsu, Masataka ; Asano, Kohichiro ; Kabe, Junzaburo ; Kudo, Kohichiro ; Shimizu, Kihachiro ; Katahira, Jun ichi ; Sakai, Osamu ; Shimada, Jingoro ; Shiba, Kohya ; Saito, Atsushi ; Shimada, Kaoru ; Fukaya, Kazufuto ; Sano, Yasuyuki ; Miyamoto, Yasufumi ; Kobayashi, Hiroyuki ; Oshitani, Hiroshi ; Takeda, Hiroaki ; Matsumoto, Fumio ; Sakurai, Iwao ; Hojo, Toshio ; Irimajiri, Shoichiro ; Obana, Mitsuo ; Odagiri, Shigeki ; Suzuki, Kaneo ; Murohashi, Kou ; Yoshioka, Teruaki ; Koyama, Izumi ; Ogura, Takashi ; Kikuchi, Norio ; Kawashima, Tatsuo ; Sekine, Osamu ; Aoki, Nobuki ; Arakawa, Masaaki ; Wada, Koichi ; Takato, Masanaga ; Hoshino, Shigeyuki ; Takeuchi, Toshihiko ; Kato, Masahito ; Hayashi, Yoshimitsu ; Hanaki, Hidekazu ; Ito, Go ; Kan, Sakae ; Miki, Fumio ; Narita, Nobuhiro ; Sawaki, Masayoshi ; Mikasa, Keiichi ; Soejima, Rinzo ; Okimoto, Jiro ; Nakagawa, Yoshihisa ; Tsukiyama, Kuninori ; Matsushima, Toshiharu ; Kawanishi, Masayoshi ; Sayvae, Yoshiro ; Kohno, Kenji ; Takita, Atsushi ; Yamane, Takatoshi ; Fukuma, Michio ; Matsumoto, Keizo ; Tanaka, Hirofumi ; Nagatake, Tsuyoshi ; Nasu, Masaru ; Yamazaki, Tohru ; Goto, Jun ; Shigeno, Hideaki ; Tashiro, Takayoshi ; Saito, Atsushi ; Irabu, Yuei ; Sakuma, Akira ; Yamaguchi, Keizo ; Sugahara, Kazuyuki ; Matsuda, Junichi ; Mochida, Chikako ; Hayashi, Chieko ; Migita, Yuji. / Double-blind comparative study on cefdinir and cefaclor in bacterial pneumonia. In: Chemotherapy. 1989 ; Vol. 37. pp. 634-659.

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title = "Double-blind comparative study on cefdinir and cefaclor in bacterial pneumonia",

abstract = "We evaluated the efficacy, safety, and usefulness of cefdinir (CFDN), a new oral cephem, in bacterial pneumonia by the multicenter double-blind comparative method using cefaclor (CCL) as a control drug. The dosage was 100 mg of CFDN t.i.d. and 500 mg of CCL t.i.d. for 14 days in principle. 1. The clinical efficacy rate judged by committee was 88.9% for CFDN and 89.9% for CCL. There was no significant difference between the two drugs. 2. In the evaluation of bacteriological effect, the eradication rate was 86.7% and 88.9% in patients given CFDN and CCL respectively. There was no significant difference between the two drugs. 3. There were no significant differences between the two drugs in the improvement rate of clinical symptoms and laboratory parameters. 4. The incidence of side effects was 4.9% in the CFDN group and 3.1% in the CCL group. The incidence of abnormal findings was 20.2% in the CFDN group and 29.5% in the CCL group. There were no significant differences between the two drugs in incidence of side effects or abnormal laboratory findings. 5. The usefulness rate was 83.8% for CFDN and 89.6% for CCL. There was no significant difference between the two drugs. The clinical efficacy, safety, and usefulness of CFDN 100mg t.i.d. were as high as those of CCL 500mg t. i. d. It is concluded that CFDN is an oral antibiotic which is clinically useful in the treatment of bacterial pneumonia.",

keywords = "Cefdinir",

author = "Kohei Hara and Masaki Hirota and Shigeru Kohno and Yasumasa Doitsu and Kazuo Sasayama and Akira Yasuoka and Hiroshi Yamada and Shigefumi Maesaki and Sadahiro Asai and Mitsuo Kaku and Hideo Mashimoto and Toshiaki Hayashi and Kiyoyasu Fukushima and Naofumi Suyama and Osamu Sakito and Yoshikazu Kawakami and Etsuro Yamaguchi and Nozomu Okazaki and Hiroshi Yamamoto and Ikuhiro Tsuneta and Akira Saito and Masumi Tomizawa and Ichiro Nakayama and Kazuo Takebe and Toyokazu Tamura and Imamura, {Ken ichi} and Masao Tamura and Kazuki Konishi and Takashi Mohri and Kazuo Obara and Yoshiaki Mori and Takashi Ito and Hitoshi Kobayashi and Tsukasa Yoshida and Takeuchi, {Ken ichi} and Toshiharu Ito and Hiromi Kanayama and Kiyoshi Konno and Kotaro Oizumi and Akira Watanabe and Seiichi Aonuma and Yushi Nakai and Saito, {Jun ichi} and Kazuo Sato and Tsuneo Sayama and Tohru Kanaya and Kohsaku Nagai and Izumi Hayashi and Masataka Katsu and Kohichiro Asano and Junzaburo Kabe and Kohichiro Kudo and Kihachiro Shimizu and Katahira, {Jun ichi} and Osamu Sakai and Jingoro Shimada and Kohya Shiba and Atsushi Saito and Kaoru Shimada and Kazufuto Fukaya and Yasuyuki Sano and Yasufumi Miyamoto and Hiroyuki Kobayashi and Hiroshi Oshitani and Hiroaki Takeda and Fumio Matsumoto and Iwao Sakurai and Toshio Hojo and Shoichiro Irimajiri and Mitsuo Obana and Shigeki Odagiri and Kaneo Suzuki and Kou Murohashi and Teruaki Yoshioka and Izumi Koyama and Takashi Ogura and Norio Kikuchi and Tatsuo Kawashima and Osamu Sekine and Nobuki Aoki and Masaaki Arakawa and Koichi Wada and Masanaga Takato and Shigeyuki Hoshino and Toshihiko Takeuchi and Masahito Kato and Yoshimitsu Hayashi and Hidekazu Hanaki and Go Ito and Sakae Kan and Fumio Miki and Nobuhiro Narita and Masayoshi Sawaki and Keiichi Mikasa and Rinzo Soejima and Jiro Okimoto and Yoshihisa Nakagawa and Kuninori Tsukiyama and Toshiharu Matsushima and Masayoshi Kawanishi and Yoshiro Sayvae and Kenji Kohno and Atsushi Takita and Takatoshi Yamane and Michio Fukuma and Keizo Matsumoto and Hirofumi Tanaka and Tsuyoshi Nagatake and Masaru Nasu and Tohru Yamazaki and Jun Goto and Hideaki Shigeno and Takayoshi Tashiro and Atsushi Saito and Yuei Irabu and Akira Sakuma and Keizo Yamaguchi and Kazuyuki Sugahara and Junichi Matsuda and Chikako Mochida and Chieko Hayashi and Yuji Migita",

year = "1989",

doi = "10.11250/chemotherapy1953.37.Supplement2_634",

language = "English",

volume = "37",

pages = "634--659",

journal = "CHEMOTHERAPY",

issn = "0009-3165",

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TY - JOUR

T1 - Double-blind comparative study on cefdinir and cefaclor in bacterial pneumonia

AU - Hara, Kohei

AU - Hirota, Masaki

AU - Kohno, Shigeru

AU - Doitsu, Yasumasa

AU - Sasayama, Kazuo

AU - Yasuoka, Akira

AU - Yamada, Hiroshi

AU - Maesaki, Shigefumi

AU - Asai, Sadahiro

AU - Kaku, Mitsuo

AU - Mashimoto, Hideo

AU - Hayashi, Toshiaki

AU - Fukushima, Kiyoyasu

AU - Suyama, Naofumi

AU - Sakito, Osamu

AU - Kawakami, Yoshikazu

AU - Yamaguchi, Etsuro

AU - Okazaki, Nozomu

AU - Yamamoto, Hiroshi

AU - Tsuneta, Ikuhiro

AU - Saito, Akira

AU - Tomizawa, Masumi

AU - Nakayama, Ichiro

AU - Takebe, Kazuo

AU - Tamura, Toyokazu

AU - Imamura, Ken ichi

AU - Tamura, Masao

AU - Konishi, Kazuki

AU - Mohri, Takashi

AU - Obara, Kazuo

AU - Mori, Yoshiaki

AU - Ito, Takashi

AU - Kobayashi, Hitoshi

AU - Yoshida, Tsukasa

AU - Takeuchi, Ken ichi

AU - Ito, Toshiharu

AU - Kanayama, Hiromi

AU - Konno, Kiyoshi

AU - Oizumi, Kotaro

AU - Watanabe, Akira

AU - Aonuma, Seiichi

AU - Nakai, Yushi

AU - Saito, Jun ichi

AU - Sato, Kazuo

AU - Sayama, Tsuneo

AU - Kanaya, Tohru

AU - Nagai, Kohsaku

AU - Hayashi, Izumi

AU - Katsu, Masataka

AU - Asano, Kohichiro

AU - Kabe, Junzaburo

AU - Kudo, Kohichiro

AU - Shimizu, Kihachiro

AU - Katahira, Jun ichi

AU - Sakai, Osamu

AU - Shimada, Jingoro

AU - Shiba, Kohya

AU - Saito, Atsushi

AU - Shimada, Kaoru

AU - Fukaya, Kazufuto

AU - Sano, Yasuyuki

AU - Miyamoto, Yasufumi

AU - Kobayashi, Hiroyuki

AU - Oshitani, Hiroshi

AU - Takeda, Hiroaki

AU - Matsumoto, Fumio

AU - Sakurai, Iwao

AU - Hojo, Toshio

AU - Irimajiri, Shoichiro

AU - Obana, Mitsuo

AU - Odagiri, Shigeki

AU - Suzuki, Kaneo

AU - Murohashi, Kou

AU - Yoshioka, Teruaki

AU - Koyama, Izumi

AU - Ogura, Takashi

AU - Kikuchi, Norio

AU - Kawashima, Tatsuo

AU - Sekine, Osamu

AU - Aoki, Nobuki

AU - Arakawa, Masaaki

AU - Wada, Koichi

AU - Takato, Masanaga

AU - Hoshino, Shigeyuki

AU - Takeuchi, Toshihiko

AU - Kato, Masahito

AU - Hayashi, Yoshimitsu

AU - Hanaki, Hidekazu

AU - Ito, Go

AU - Kan, Sakae

AU - Miki, Fumio

AU - Narita, Nobuhiro

AU - Sawaki, Masayoshi

AU - Mikasa, Keiichi

AU - Soejima, Rinzo

AU - Okimoto, Jiro

AU - Nakagawa, Yoshihisa

AU - Tsukiyama, Kuninori

AU - Matsushima, Toshiharu

AU - Kawanishi, Masayoshi

AU - Sayvae, Yoshiro

AU - Kohno, Kenji

AU - Takita, Atsushi

AU - Yamane, Takatoshi

AU - Fukuma, Michio

AU - Matsumoto, Keizo

AU - Tanaka, Hirofumi

AU - Nagatake, Tsuyoshi

AU - Nasu, Masaru

AU - Yamazaki, Tohru

AU - Goto, Jun

AU - Shigeno, Hideaki

AU - Tashiro, Takayoshi

AU - Saito, Atsushi

AU - Irabu, Yuei

AU - Sakuma, Akira

AU - Yamaguchi, Keizo

AU - Sugahara, Kazuyuki

AU - Matsuda, Junichi

AU - Mochida, Chikako

AU - Hayashi, Chieko

AU - Migita, Yuji

PY - 1989

Y1 - 1989

N2 - We evaluated the efficacy, safety, and usefulness of cefdinir (CFDN), a new oral cephem, in bacterial pneumonia by the multicenter double-blind comparative method using cefaclor (CCL) as a control drug. The dosage was 100 mg of CFDN t.i.d. and 500 mg of CCL t.i.d. for 14 days in principle. 1. The clinical efficacy rate judged by committee was 88.9% for CFDN and 89.9% for CCL. There was no significant difference between the two drugs. 2. In the evaluation of bacteriological effect, the eradication rate was 86.7% and 88.9% in patients given CFDN and CCL respectively. There was no significant difference between the two drugs. 3. There were no significant differences between the two drugs in the improvement rate of clinical symptoms and laboratory parameters. 4. The incidence of side effects was 4.9% in the CFDN group and 3.1% in the CCL group. The incidence of abnormal findings was 20.2% in the CFDN group and 29.5% in the CCL group. There were no significant differences between the two drugs in incidence of side effects or abnormal laboratory findings. 5. The usefulness rate was 83.8% for CFDN and 89.6% for CCL. There was no significant difference between the two drugs. The clinical efficacy, safety, and usefulness of CFDN 100mg t.i.d. were as high as those of CCL 500mg t. i. d. It is concluded that CFDN is an oral antibiotic which is clinically useful in the treatment of bacterial pneumonia.

AB - We evaluated the efficacy, safety, and usefulness of cefdinir (CFDN), a new oral cephem, in bacterial pneumonia by the multicenter double-blind comparative method using cefaclor (CCL) as a control drug. The dosage was 100 mg of CFDN t.i.d. and 500 mg of CCL t.i.d. for 14 days in principle. 1. The clinical efficacy rate judged by committee was 88.9% for CFDN and 89.9% for CCL. There was no significant difference between the two drugs. 2. In the evaluation of bacteriological effect, the eradication rate was 86.7% and 88.9% in patients given CFDN and CCL respectively. There was no significant difference between the two drugs. 3. There were no significant differences between the two drugs in the improvement rate of clinical symptoms and laboratory parameters. 4. The incidence of side effects was 4.9% in the CFDN group and 3.1% in the CCL group. The incidence of abnormal findings was 20.2% in the CFDN group and 29.5% in the CCL group. There were no significant differences between the two drugs in incidence of side effects or abnormal laboratory findings. 5. The usefulness rate was 83.8% for CFDN and 89.6% for CCL. There was no significant difference between the two drugs. The clinical efficacy, safety, and usefulness of CFDN 100mg t.i.d. were as high as those of CCL 500mg t. i. d. It is concluded that CFDN is an oral antibiotic which is clinically useful in the treatment of bacterial pneumonia.

KW - Cefdinir

UR - http://www.scopus.com/inward/record.url?scp=0024815533&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024815533&partnerID=8YFLogxK

U2 - 10.11250/chemotherapy1953.37.Supplement2_634

DO - 10.11250/chemotherapy1953.37.Supplement2_634

M3 - Article

AN - SCOPUS:0024815533

VL - 37

SP - 634

EP - 659

JO - CHEMOTHERAPY

JF - CHEMOTHERAPY

SN - 0009-3165

ER -

Double-blind comparative study on cefdinir and cefaclor in bacterial pneumonia

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