Double-blind comparative study on cefdinir and cefaclor in bacterial pneumonia

Kohei Hara, Masaki Hirota, Shigeru Kohno, Yasumasa Doitsu, Kazuo Sasayama, Akira Yasuoka, Hiroshi Yamada, Shigefumi Maesaki, Sadahiro Asai, Mitsuo Kaku, Hideo Mashimoto, Toshiaki Hayashi, Kiyoyasu Fukushima, Naofumi Suyama, Osamu Sakito, Yoshikazu Kawakami, Etsuro Yamaguchi, Nozomu Okazaki, Hiroshi Yamamoto, Ikuhiro TsunetaAkira Saito, Masumi Tomizawa, Ichiro Nakayama, Kazuo Takebe, Toyokazu Tamura, Ken ichi Imamura, Masao Tamura, Kazuki Konishi, Takashi Mohri, Kazuo Obara, Yoshiaki Mori, Takashi Ito, Hitoshi Kobayashi, Tsukasa Yoshida, Ken ichi Takeuchi, Toshiharu Ito, Hiromi Kanayama, Kiyoshi Konno, Kotaro Oizumi, Akira Watanabe, Seiichi Aonuma, Yushi Nakai, Jun ichi Saito, Kazuo Sato, Tsuneo Sayama, Tohru Kanaya, Kohsaku Nagai, Izumi Hayashi, Masataka Katsu, Kohichiro Asano, Junzaburo Kabe, Kohichiro Kudo, Kihachiro Shimizu, Jun ichi Katahira, Osamu Sakai, Jingoro Shimada, Kohya Shiba, Atsushi Saito, Kaoru Shimada, Kazufuto Fukaya, Yasuyuki Sano, Yasufumi Miyamoto, Hiroyuki Kobayashi, Hiroshi Oshitani, Hiroaki Takeda, Fumio Matsumoto, Iwao Sakurai, Toshio Hojo, Shoichiro Irimajiri, Mitsuo Obana, Shigeki Odagiri, Kaneo Suzuki, Kou Murohashi, Teruaki Yoshioka, Izumi Koyama, Takashi Ogura, Norio Kikuchi, Tatsuo Kawashima, Osamu Sekine, Nobuki Aoki, Masaaki Arakawa, Koichi Wada, Masanaga Takato, Shigeyuki Hoshino, Toshihiko Takeuchi, Masahito Kato, Yoshimitsu Hayashi, Hidekazu Hanaki, Go Ito, Sakae Kan, Fumio Miki, Nobuhiro Narita, Masayoshi Sawaki, Keiichi Mikasa, Rinzo Soejima, Jiro Okimoto, Yoshihisa Nakagawa, Kuninori Tsukiyama, Toshiharu Matsushima, Masayoshi Kawanishi, Yoshiro Sayvae, Kenji Kohno, Atsushi Takita, Takatoshi Yamane, Michio Fukuma, Keizo Matsumoto, Hirofumi Tanaka, Tsuyoshi Nagatake, Masaru Nasu, Tohru Yamazaki, Jun Goto, Hideaki Shigeno, Takayoshi Tashiro, Atsushi Saito, Yuei Irabu, Akira Sakuma, Keizo Yamaguchi, Kazuyuki Sugahara, Junichi Matsuda, Chikako Mochida, Chieko Hayashi, Yuji Migita

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We evaluated the efficacy, safety, and usefulness of cefdinir (CFDN), a new oral cephem, in bacterial pneumonia by the multicenter double-blind comparative method using cefaclor (CCL) as a control drug. The dosage was 100 mg of CFDN t.i.d. and 500 mg of CCL t.i.d. for 14 days in principle. 1. The clinical efficacy rate judged by committee was 88.9% for CFDN and 89.9% for CCL. There was no significant difference between the two drugs. 2. In the evaluation of bacteriological effect, the eradication rate was 86.7% and 88.9% in patients given CFDN and CCL respectively. There was no significant difference between the two drugs. 3. There were no significant differences between the two drugs in the improvement rate of clinical symptoms and laboratory parameters. 4. The incidence of side effects was 4.9% in the CFDN group and 3.1% in the CCL group. The incidence of abnormal findings was 20.2% in the CFDN group and 29.5% in the CCL group. There were no significant differences between the two drugs in incidence of side effects or abnormal laboratory findings. 5. The usefulness rate was 83.8% for CFDN and 89.6% for CCL. There was no significant difference between the two drugs. The clinical efficacy, safety, and usefulness of CFDN 100mg t.i.d. were as high as those of CCL 500mg t. i. d. It is concluded that CFDN is an oral antibiotic which is clinically useful in the treatment of bacterial pneumonia.

Original languageEnglish
Pages (from-to)634-659
Number of pages26
JournalChemotherapy
Volume37
DOIs
Publication statusPublished - 1989

Keywords

  • Cefdinir

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology
  • Drug Discovery
  • Oncology

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