Double-blind and placebo-controlled study of the effectiveness and safety of extracorporeal cardiac shock wave therapy for severe angina pectoris

Yoku Kikuchi; Kenta Ito; Yoshitaka Ito; Takashi Shiroto; Ryuji Tsuburaya; Kentaro Aizawa; Kiyotaka Hao; Yoshihiro Fukumoto; Jun Takahashi; Morihiko Takeda; Masaharu Nakayama; Satoshi Yasuda; Shinichi Kuriyama; Ichiro Tsuji; Hiroaki Shimokawa

doi:10.1253/circj.CJ-09-1028

Double-blind and placebo-controlled study of the effectiveness and safety of extracorporeal cardiac shock wave therapy for severe angina pectoris

Yoku Kikuchi, Kenta Ito, Yoshitaka Ito, Takashi Shiroto, Ryuji Tsuburaya, Kentaro Aizawa, Kiyotaka Hao, Yoshihiro Fukumoto, Jun Takahashi, Morihiko Takeda, Masaharu Nakayama, Satoshi Yasuda, Shinichi Kuriyama, Ichiro Tsuji, Hiroaki Shimokawa

Research output: Contribution to journal › Article

99 Citations (Scopus)

Abstract

Background: Low-energy shock wave (SW) therapy has improved myocardial ischemia in both a porcine model and in patients with severe angina pectoris. Methods and Results: To further confirm the effectiveness and safety of SW therapy, 8 patients with severe angina pectoris were treated with SW therapy in a double-blind, placebo-controlled and cross-over manner. SW therapy, but not placebo, significantly improved chest pain symptoms and cardiac function without any complications or adverse effects. Conclusions: Extracorporeal cardiac SW therapy is an effective, safe and non-invasive therapeutic option for severe angina pectoris.

Original language	English
Pages (from-to)	589-591
Number of pages	3
Journal	Circulation Journal
Volume	74
Issue number	3
DOIs	https://doi.org/10.1253/circj.CJ-09-1028
Publication status	Published - 2010 Mar

Keywords

Angina pectoris
Angiogenesis
Myocardial ischemia
Shock wave

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1253/circj.CJ-09-1028

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Kikuchi, Y., Ito, K., Ito, Y., Shiroto, T., Tsuburaya, R., Aizawa, K., Hao, K., Fukumoto, Y., Takahashi, J., Takeda, M., Nakayama, M., Yasuda, S., Kuriyama, S., Tsuji, I., & Shimokawa, H. (2010). Double-blind and placebo-controlled study of the effectiveness and safety of extracorporeal cardiac shock wave therapy for severe angina pectoris. Circulation Journal, 74(3), 589-591. https://doi.org/10.1253/circj.CJ-09-1028

Double-blind and placebo-controlled study of the effectiveness and safety of extracorporeal cardiac shock wave therapy for severe angina pectoris. / Kikuchi, Yoku; Ito, Kenta; Ito, Yoshitaka; Shiroto, Takashi; Tsuburaya, Ryuji; Aizawa, Kentaro; Hao, Kiyotaka; Fukumoto, Yoshihiro; Takahashi, Jun; Takeda, Morihiko; Nakayama, Masaharu; Yasuda, Satoshi; Kuriyama, Shinichi ; Tsuji, Ichiro; Shimokawa, Hiroaki.

In: Circulation Journal, Vol. 74, No. 3, 03.2010, p. 589-591.

Research output: Contribution to journal › Article

Kikuchi, Y, Ito, K, Ito, Y, Shiroto, T, Tsuburaya, R, Aizawa, K, Hao, K, Fukumoto, Y, Takahashi, J, Takeda, M, Nakayama, M, Yasuda, S, Kuriyama, S , Tsuji, I & Shimokawa, H 2010, 'Double-blind and placebo-controlled study of the effectiveness and safety of extracorporeal cardiac shock wave therapy for severe angina pectoris', Circulation Journal, vol. 74, no. 3, pp. 589-591. https://doi.org/10.1253/circj.CJ-09-1028

Kikuchi, Yoku ; Ito, Kenta ; Ito, Yoshitaka ; Shiroto, Takashi ; Tsuburaya, Ryuji ; Aizawa, Kentaro ; Hao, Kiyotaka ; Fukumoto, Yoshihiro ; Takahashi, Jun ; Takeda, Morihiko ; Nakayama, Masaharu ; Yasuda, Satoshi ; Kuriyama, Shinichi ; Tsuji, Ichiro ; Shimokawa, Hiroaki. / Double-blind and placebo-controlled study of the effectiveness and safety of extracorporeal cardiac shock wave therapy for severe angina pectoris. In: Circulation Journal. 2010 ; Vol. 74, No. 3. pp. 589-591.

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AU - Shiroto, Takashi

AU - Tsuburaya, Ryuji

AU - Aizawa, Kentaro

AU - Hao, Kiyotaka

AU - Fukumoto, Yoshihiro

AU - Takahashi, Jun

AU - Takeda, Morihiko

AU - Nakayama, Masaharu

AU - Yasuda, Satoshi

AU - Kuriyama, Shinichi

AU - Tsuji, Ichiro

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AB - Background: Low-energy shock wave (SW) therapy has improved myocardial ischemia in both a porcine model and in patients with severe angina pectoris. Methods and Results: To further confirm the effectiveness and safety of SW therapy, 8 patients with severe angina pectoris were treated with SW therapy in a double-blind, placebo-controlled and cross-over manner. SW therapy, but not placebo, significantly improved chest pain symptoms and cardiac function without any complications or adverse effects. Conclusions: Extracorporeal cardiac SW therapy is an effective, safe and non-invasive therapeutic option for severe angina pectoris.

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KW - Angiogenesis

KW - Myocardial ischemia

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