Dosimetry and radiation dose distribution in tumors for radioimmunotherapy: The effect of tumor size

K. Fujimori, M. Furudate

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

For aiding to optimize the efficiency of radioimmunotherapy with β-emitter-labeled monoclonal antibody (MAb), radiation absorbed dose in a small tumor was calculated using a mathematical model for 67Cu, 90Y, 131I, 186Re, and 188Re. MAb distributions were assumed to be uniform or exponential to investigate the tumor size effect on absorbed dose. The salient results are 1) with longer range β-emitters, radiation absorbed dose is increased with the tumor size increases and the fraction of radiation dose to the outside of the tumor is large; 2) with shorter range β-emitters, the tumor size effect on absorbed dose is small. The fraction of radiation dose to the tumor is large and small tumors will be irradiated effectively; 3) when MAb distribution is non-uniform, absorbed dose is more homogenous with longer range β-emitters.

Original languageEnglish
Pages (from-to)241-248
Number of pages8
JournalKakuigaku
Volume31
Issue number3
Publication statusPublished - 1994 Jan 1
Externally publishedYes

Keywords

  • dosimetry
  • monoclonal antibody
  • radioimmunotherapy
  • radionuclides
  • tumor size

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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