TY - JOUR
T1 - Dopaminergic and serotonergic modulation of anterior insular and orbitofrontal cortex function in risky decision making
AU - Ishii, Hironori
AU - Ohara, Shinya
AU - Tobler, Philippe N.
AU - Tsutsui, Ken Ichiro
AU - Iijima, Toshio
N1 - Funding Information:
This study was supported by a Global Common Operating Environment Program of the Japanese Ministry of Education, Culture, Sports, Science and Technology in the form of the “Basic and Translational Research Center for Global Brain Science” at Tohoku University. PNT was supported by Grants PP00P1_128574 , PP00P1_150739 , and CRSII3_141965 from the Swiss National Science Foundation .
Publisher Copyright:
© 2014 Elsevier Ireland Ltd and the Japan Neuroscience Society.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Systemic manipulations have shown that dopamine and serotonin systems are involved in risky decision making. However, how they work within the regions that implement risky choices remains unclear. The present study investigated the role of dopamine and serotonin in the rat anterior insular cortex (AIC) and orbitofrontal cortex (OFC), which make different contributions to risky decision making. We examined the effects of local injection of the D1 (SCH23390), D2 (eticlopride), 5-HT1A (WAY100635) and 5-HT2A (M100907) receptor antagonists into the AIC or OFC on risk preference in a gambling task. We found that different dopamine and serotonin receptor subtypes in the AIC and OFC differentially influence risky decision making: intra-AIC injection of D2R or 5-HT1AR blockers increased risk preference whereas intra-OFC injection of the 5-HT1AR blocker decreased it. Risk preference was not altered by intra-AIC injection of D1R and 5-HT2AR blockers or by intra-OFC injection of D1R, D2R, and 5-HT2AR blockers. Furthermore, additional analyses revealed that dopamine and serotonin signaling in the AIC have outcome history-dependent effects on risk taking: intra-AIC injection of the D2R blocker increased risk preference particularly after winning in a previous risky choice, whereas intra-AIC injection of the 5-HT1AR blocker increased risk preference after losing.
AB - Systemic manipulations have shown that dopamine and serotonin systems are involved in risky decision making. However, how they work within the regions that implement risky choices remains unclear. The present study investigated the role of dopamine and serotonin in the rat anterior insular cortex (AIC) and orbitofrontal cortex (OFC), which make different contributions to risky decision making. We examined the effects of local injection of the D1 (SCH23390), D2 (eticlopride), 5-HT1A (WAY100635) and 5-HT2A (M100907) receptor antagonists into the AIC or OFC on risk preference in a gambling task. We found that different dopamine and serotonin receptor subtypes in the AIC and OFC differentially influence risky decision making: intra-AIC injection of D2R or 5-HT1AR blockers increased risk preference whereas intra-OFC injection of the 5-HT1AR blocker decreased it. Risk preference was not altered by intra-AIC injection of D1R and 5-HT2AR blockers or by intra-OFC injection of D1R, D2R, and 5-HT2AR blockers. Furthermore, additional analyses revealed that dopamine and serotonin signaling in the AIC have outcome history-dependent effects on risk taking: intra-AIC injection of the D2R blocker increased risk preference particularly after winning in a previous risky choice, whereas intra-AIC injection of the 5-HT1AR blocker increased risk preference after losing.
KW - Gambling
KW - Rat
KW - Reward
KW - Risk-based decision making
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U2 - 10.1016/j.neures.2014.11.009
DO - 10.1016/j.neures.2014.11.009
M3 - Article
C2 - 25481848
AN - SCOPUS:84923572341
VL - 92
SP - 53
EP - 61
JO - Neuroscience Research
JF - Neuroscience Research
SN - 0168-0102
ER -