Donor lymphocyte infusion for the treatment of relapsed acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation: A retrospective analysis by the adult acute myeloid leukemia working group of the Japan society for hematopoietic cell transplantation

Akiyoshi Takami, Shingo Yano, Hiroki Yokoyama, Yachiyo Kuwatsuka, Takuhiro Yamaguchi, Yoshinobu Kanda, Yasuo Morishima, Takahiro Fukuda, Yasushi Miyazaki, Hirohisa Nakamae, Junji Tanaka, Yoshiko Atsuta, Heiwa Kanamori

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Because the efficacy of donor lymphocyte infusion (DLI) for acute myeloid leukemia (AML) relapse after allogeneic hematopoietic stem cell transplantation (HSCT) remains uncertain, especially in the Asian population, a nationwide registry study was retrospectively performed by the Adult AML Working Group of the Japan Society for Hematopoietic Cell Transplantation to identify the factors affecting the patient survival after DLI. Among 143 adult AML patients who received DLI for the treatment of first hematological relapse after HSCT, the overall survival rates at 1year, 2years, and 5years were 32%±4%, 17%±3%, and 7%±3%, respectively. Complete remission (CR) at the time of DLI, which was obtained in 8% of the patients, was the strongest predictive factor for survival after DLI. Therefore, long-term survival after DLI was achieved almost exclusively in patients who successfully achieved a CR before DLI, indicating the limited efficacy of DLI in a minority of patients.

Original languageEnglish
Pages (from-to)1785-1790
Number of pages6
JournalBiology of Blood and Marrow Transplantation
Volume20
Issue number11
DOIs
Publication statusPublished - 2014 Nov 1

Keywords

  • Acute myeloid leukemia
  • Complete remission
  • Donor lymphocyte infusion

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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