Domino michael/michael reaction for the formation of chiral spirocycles using a diphenylprolinol silyl ether

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Abstract

A domino Michael/Michael reaction of 2-(2-formyl-ethyl)naphthalene-1,4-dione and nitroalkene was catalyzed by diphenylprolinol silyl ether to afford functionalized spiro[cyclo-pentane-1,2′(1′H)-naphthalene] derivatives with four continuous stereocenters in good yields with excellent diastereo-and enantioselectivities.

Original languageEnglish
Pages (from-to)678-681
Number of pages4
JournalEuropean Journal of Organic Chemistry
Volume2019
Issue number4
DOIs
Publication statusPublished - 2019 Jan 31

Keywords

  • Asymmetric synthesis
  • Domino reactions
  • Organocatalysis
  • Spirocycles
  • Synthetic methods

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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