Do the antithrombotic therapy at the time of intracerebral hemorrhage influence clinical outcome? analysis between the difference of antiplatelet and anticoagulant agents and clinical course

Takeshi Okada, Taizen Nakase, Masahiro Sasaki, Tatsuya Ishikawa

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Background It is controversial whether taking antiplatelet agents (APs) or anticoagulant agents (ACs) could influence clinical outcome after intracerebral hemorrhage (ICH). Methods We retrospectively investigated 557 ICH patients between September 2008 and August 2013. We reviewed patients' characteristics, hematoma volume, deterioration (hematoma expansion, surgical hematoma evacuation, or death), and clinical outcome in modified Rankin Scale. Results A total of 397 were classified as neither AP nor AC (Nothing), 81 as single AP (44 as aspirin [ASA], 22 as clopidogrel or ticlopidine [CLP/TIC], 7 as cilostazol, 8 as dual antiplatelet therapy), 43 as single AC (40 as warfarin, 2 as rivaroxaban, 1 as dabigatran), and 36 as both AP and AC (AP + AC). The clinical outcome was worse in APs than in Nothing (P =.021). Among APs, CLP/TIC showed poorer clinical outcome than ASA (P =.020). Deterioration was observed more frequently in AC than in Nothing (P <.001) and the clinical outcome was also worse in AC than in Nothing (P <.001). AP + AC use resulted in deterioration more frequently than Nothing (P <.001) and in poorer outcome than in Nothing (P <.001). Conclusions The use of antithrombotic agents could be associated with the deterioration after admission and the poor clinical outcome. CLP/TIC use may affect the poor outcome compared with ASA use.

Original languageEnglish
Pages (from-to)1781-1788
Number of pages8
JournalJournal of Stroke and Cerebrovascular Diseases
Volume23
Issue number7
DOIs
Publication statusPublished - 2014 Aug
Externally publishedYes

Keywords

  • anticoagulant
  • antiplatelet
  • clinical outcome
  • Intracerebral hemorrhage

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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